Tuesday, 23 March 2010

Vitamin D status is associated with relapse rate in pediatric-onset MS

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Among 110 North American paediatric CIS/MS subjects, every 10 ng/mL increase in the adjusted 25 hydroxyvitamin D3 level was associated with a 34% decrease in the rate of subsequent relapses.
This study adds compelling evidence in support of a role for vitamin D in reducing MS relapse rates as initially seen in smaller studies in adult MS cohorts (Wingerchuk et al, JNNP 2005; Soilu-Hänninen et al, JNNP, 2008). As vitamin D deficiency/insufficiency is endemic worldwide (Holick, NEJM, 2007), further studies of vitamin D as a treatment measure in MS are warranted.

Sreeram Ramagopalan

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