Sunday, 5 September 2010

No association between allergies and multiple sclerosis

Different types of inflammation are defined by immunologists by the type of cells and the mediators used by these cells.

The current dogma: inflammation in MS is mediated by either T-helper one (Th1) or T-helper 17 (Th17) cells. In comparison, allergies are due to a T-helper two (Th2) immune response, which may be protective in MS.

A large analysis of all published studies on allergic disease and MS provides no evidence of a positive or negative association between the allergic diseases asthma , allergic rhinitis and eczema.

Implications: this analysis challenges the current dogma and also raises questions about the treatment strategy of trying to stimulate Th2 immunity in PwMS; e.g. by promoting parasitic infections of the gut.

Click here for abstract: Monteiro et al. Acta Neurol Scand. 2010 Apr 29 (Epub ahead of print)

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