Drug-the Game Part III

As you have seen the pecha kuca from Prof G
I present mine in a much more low tech way. Drug-Game Part I, Drug-Game Part II

Why Does it take So Long to Develop a Drug For MSers
Find Out! Play.......Drug

So you all know the Rules, How much is it Going to Cost?
Alot


Whats on the Cards?


Financial Zone (FZ)
Charity Funding
Grant Funded-Role Dice For Amount
Grant Needs Rewriting-Try Again Next Turn
Grant Rejected
-Miss a Turn and Try Again
Grant Rejected-Return to Start
Not Enough Funds-Miss a Turn
Project funded byPhilantropists-Role Dice For Amount
Project funded byVenture Capitalist-Role Dice For Amount
Charity changes Priorities- Return to Start

Company Funding
(a)
Project Funded-Role Dice For Amount
Company Change Priorities. Drug Project Dropped. Go back to Charity Route
Company Merged. Drug Project Dropped. Go back to Charity Route
Company Merged. Drug Project Fast-Tracked: Role Dice for amount + Gain £2,000,000
Funded by Bad Profits Forcast-Role the Dice For Amount and Half-it.


Chemistry (Chem) Results
Drug has not Detectable Issues that Prevent Development--Proceed to Toxicology
Drug causes Degradation of Other Drugs-Drug Fails.Back to Start
Drug causes Degradation of Other Drugs-Need More Chemistry-Go Back to Microscope
Drug causes Mutations in cells.Drug Fails.Back to Start
Drug causes Mutations in cells-Need More Chemistry-Go Back to Microscope
Drug doesn't work in EAE.Drug Fails.Back to Start
Drug doesn't work in EAE.Need More Chemistry-Go Back to Microscope
Drug may cause tumour growth-Drug Fails.Back to Start
Drug may cause heart problem-Drug Fails.Back to Start
Drug may cause heart problem--Need More Chemistry-Go Back to Microscope
Drug can not be delivered using a Pill,-Use Injectable-Miss a turn & Proceed to Toxicology
Drug can not be delivered using a Pill, Drug Fails-Go Back to Start
Drug can not be delivered using a Pill, Need More Chemistry-Go Back to Microscope
Drug is rapidly Degraded. Drug Fails-Go Back to Start
Drug is rapidly Degraded. Need More Chemistry-Go Back to Microscope
Drug is rapidly Degraded. Need More Chemistry and EAE study-Go Back to Microscope/Mouse
Drug can't get into Brain. Drug Fails-Go Back to Start
Drug can't get into Brain. Need More Chemistry-Go Back to Microscope
Lawyers Did Not File Patent at Start. Competitor has Patent.Project Fails-Go Back to Start
Lawyers Did Not File Patent at Start. Now Filed. Extra £20 million at Completion
Patent Validity is Challenged. Win case Lose £100,000 and Proceed to Toxicology
Patent Validity is Challenged. Lose £100,000 and Go back to Start
Pharmaceutical company buys the drug-Use Company FZ
Pharmaceutical company buys the drug-Get £1,000,000 & Use Company FZ
Pharmaceutical company buys the drug-Get £3,000,000 & Use Company FZ

Toxicology (Tox) Results

Before being used in humans currrently drugs must be tested on animals (one small mammal species and one large animal species) for the length of time that human trials will take
Animals All Healthy-Proceed to Ethics

Problem with Large Animal Study, Repeat-Back to Rabbit.
Animal Death, Maybe Technical reason, Repeat-Back to Rat.
Animals Death, Project Fails-Go back Start
Animals Death, Repeat Chemistry of Drug-Go back to Microscope
Damage in Tissues, Maybe Technical reason, Repeat-Back to Rat.
Damage in Tissues, Project Fails-Go back Start
Damage in Tissues, Repeat Chemistry of Drug-Go back to Microscope
Animals All Healthy, but need to check higher Drug Dose-Back to Rat
Pharmaceutical company buys the drug-Use Company FZ
Pharmaceutical company buys the drug-Get £2,000,000 & Use Company FZ
Pharmaceutical company buys the drug to stop development. Miss 4 turns + loose £100,000
Lawyers Did Not File Patent at Start. Competitor has Patent.Project Fails-Back to Start
Lawyers Did Not File Patent at Start. Now Filed. Extra £50 million at Completion-Go to Ethics
Patent Validity is Challenged. Win case Lose £100,000 and Proceed to Toxicology
Patent Validity is Challenged. Lose £100,000 and Go back to Start

Ethical (E) Review
All procedures in humans must be approved by an Independent Ethical Review board. People on trial must give informed consent such that they agree to participate and understand the risks of doing so.
Ethically Sound-Proceed to Phase I

Paperwork Not in Order,Resubmit-Miss a turn
Ethical Case Not Made,Resubmit- Miss a turn


Phase I Results
No Adverse Effects-Proceed to Phase II
Drug gets broken down quickly-Reformulate-Go back to chemistry.
Drug induced side-effect. Start again at Chemistry
Drug induced Side-Effect. Start again.
Pharmaceutical company buys the drug-Use Company FZ. Proceed
Pharmaceutical company buys the drug-Get £2,000,000 & Use Company FZ
Pharmaceutical company buys the drug to stop development. Miss 4 turns + loose £100,000
Phase II Interim Analysis (IA)
A independent panel of Doctors ass the the results half way through the study to check if there are safety issues that warrant stopping the trial.
No Health Issues Identified. Continue Trial
Health Issue Identified. Trial Stopped. Go back to Start
Drug is Working So Well. Not Ethical to Continue with Placebo Group. Trial Stopped-Go to Phase III
Placebo Group not Progressing so Positive Results Not Possible. Repeat Trial. Go back to Phase II

Phase II Results (IIR)
No Adverse Effects-Proceed to Phase II
No Adverse Effects and seems to be working-Proceed to Phase II
Drug induced side-effect. Start again at Chemistry
Drug induced Side-Effect. Start again.
Drug causes Cancer. Start again.
Drug causes Infection. Decide How to Mnitor and Treat. Miss Two Turns
Pharmaceutical company buys the drug-Use Company FZ. Proceed

Phase III Results (IIR)
You have to state what the main outcome will be before the trial starts. If that main effect is not found, its a failure even if it has an affect on a other outcomes.
No Adverse Effects and Treats MS-Proceed to Regulatory Approval
No Adverse Effects but Does No. Return to Start
Drug fails to Change One symptom, but treats other symptoms. Repeat Trial
Drug induced side-effect. Start again at Chemistry
Drug induced Side-Effect. Start again.
Drug causes Cancer. Start again.
Drug causes Infection. Decide How to Mnitor and Treat. Miss Two Turns
Pharmaceutical company buys the drug-Use Company FZ. Proceed

Regulatory Approval (FDA/EMA)
To market/sell a drug comes approval is needed from the FDA (Food and Drug Administration, USA) and EMA (European Medicines Ageny, Europe).

Drug Appoved-Throw a Six to Cross Finishing Line and Start Selling the Drug
Paperwork Not in Order-Miss Two Turns and Try Again
Regulators want more Safety Data-Repeat Phase III Trial
Regulators want more Safety Data-Company Pull Out. Back to Start
Regulators want more Safety Data-Company Pull Out, Repeat Phase III Trial with Charity
Regulators want more Efficacy Data-Repeat Phase III Trial
Regulators want more Efficacy Data-Repeat Phase III Trial. Back to Start
Regulators want more Efficacy Data-Company Pull Out Repeat Phase III Trial with Charity


I think you can seee that it is not easy to win and it may take along time to get round the board

Do you have Suggestions...Constructive Please........
Could we make this into an Actual Game?


To be continued
.