Monday, 3 October 2011

Immune complications of alemtuzumab

Epub ahead of printCuker et al. A distinctive form of immune thrombocytopenia in a phase 2 study of alemtuzumab for the treatment of relapsing-remitting multiple sclerosis. Blood. 2011 Sep 29.


In a phase 2 clinical trial of annual alemtuzumab for the treatment of relapsing-remitting MS, 6/216 (2.8%) patients developed immune thrombocytopenia (ITP). 

"Thrombocytes or platelets are the cells in the blood responsible for clotting; ITP occurs when your immune system makes antibodies (proteins) that attack and destroy the platelets. This is potentially a very serious condition and if the platelet counts drops very low you can die from excessive bleeding."

Over a mean follow-up of 4.5 years, the incidence rate of ITP was 6.2 (95% CI 2.3-13.3) per 1000 person-years. The average times from initial and last alemtuzumab exposure to ITP diagnosis were 24.5 and 10.5 months, respectively. Five patients developed severe thrombocytopenia. Four were symptomatic, including fatal intracranial hemorrhage in the index case. Four patients received standard first-line therapy for ITP, all of whom responded to treatment within 1 week. All 5 surviving patients achieved complete remission and remained in remission without the need for ongoing ITP therapy for a median duration of 34 months at last follow-up. A monitoring plan for the early detection of ITP, implemented after presentation of the index case, identified all 5 subsequent cases before serious haemorrhage or death occurred. 

Conclusion: The researchers describe a distinctive form of ITP associated with alemtuzumab treatment characterized by delayed presentation after drug exposure, responsiveness to conventional ITP therapies, and prolonged remission. Clinicians should maintain a high level of vigilance and consider routine monitoring for ITP in patients treated with this agent. 

"How do you know if you have ITP? You need to look out for early signs of bleeding; for example easy bruising, bleeding from the gums, petechiae or petechial rash (see below), blood in the urine (coca cola urine)."

"The treatment of ITP usually involved steroids and if that fails the intravenous infusion of high-dose immunoglobulins, called IVIG. Other more aggressive therapies are also available."

"The ITP and other autoimmune complications of alemtuzumab therapy are in my opinion the biggest hurdle for this drug been adopted early in the course of MS when it is likely to have its greatest impact. The other hurdle already discussed on this blog is the price of the drug."

Purpura of the type associated with ITP

Additional reading: ITP, alemtuzumab


Related posts:


11 Sep 2011
"Based on its superior efficacy Alemtuzumab should command a premium price. However, the cost will affect its cost-effectiveness and its license in the UK under NICE. Ideally we would like to use Alemtuzumab in early MS; ...
09 Sep 2011
This is more of the same (good) news, with regard to Alemtuzumab. This un-controlled and unblinded study indicates that Alemtuzumab (an antibody that kills white blood cells) quells disease activity in MSers who have ...
30 Jul 2011
"What is alemtuzumab? You may know the drug as Campath-1h. This is a powerful immuno-modulator that is given as a course of intravenous infusions. It depletes the immune system and allows it to recover. I refer to it as an ...
18 Jul 2011
"This was not a negative study; Alemtuzumab is still a very promising disease-modifying therapy! The patients in this trial were less active than previously therefore the trial lacked power to detect a difference in relation to ...

3 comments:

  1. Poor foot.

    Side effects are a real concern. MS os such a powerful disease that it will always need seriously powful drugs tro try treat it.

    Therein lies the problem.

    ReplyDelete
  2. Re: "Therein lies the problem."

    Not necessarily; if MS'ers are educated and are aware of the risks associated with the treatment aren't they in the best position to make a choice? A previous survey on this blog established that point. However, not everyone is up for making decisions and that is were we have have to help.

    ReplyDelete
  3. felt great after the 1st treatment the 2nd I don't feel any progress

    ReplyDelete

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