Cerebrospinal fluid samples collected from children during initial presentation of CNS-inflammation, that may or may not subsequently be diagnosed as multiple sclerosis (MS), were subjected to large-scale proteomics screen. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon-glial interactions in those children destined for diagnosis of MS.
If we look at the cerebrospinal fluid from children with neurological symptoms and then look at whether they go on to develop MS or not, thoses that developed MS, showed evidence of damage to the nodes of ranvier, rather than oligodendrocyte and myelin proteins. Therefore, are the early targets in MS, nerve conduction proteins rather than myelin. Yet further dints in the autoimmune hypothesis perhaps.