"George Ebers told me that initially this twin did very well; her disability improved and she stabilised without any relapses - she appeared to have burnt out MS. Was she cured? Unfortunately not, about 7 years after her BMT she developed SPMS. This observation would support MS as being a primary neurodegenerative disease. What do you think?"
"This case is not a good example; as she has quite advanced disease and had already acquired a lot of damage she was destined to develop progressive disease. Why should someone with a damaged nervous system be primed for progression? That is another story, possibly another grand challenge."
"I hope this post in not confusing; if it is I will try and simplify the concepts!"