Monday, 9 July 2012

Research: BoTox for Tremor

OBJECTIVE: To evaluate the safety and efficacy of botulinum toxin type A in disabling multiple sclerosis (MS)-related upper limb tremor.

METHODS: Twenty-three patients with MS contributed data from 33 upper limbs to this study. Each limb was randomized in a crossover design to receive botulinum toxin type A or placebo at baseline and the reverse treatment at 12 weeks. The 3 main outcomes were the median changes in Bain tremor rating scores for tremor severity, writing, and drawing an Archimedes spiral from baseline to 6 and 12 weeks after treatment with botulinum toxin type A compared with those after treatment with saline placebo. An independent rater scored randomized video assessments performed every 6 weeks over 6 months.

RESULTS: There was a significant improvement after botulinum toxin compared with that after placebo treatment in the Bain score for tremor severity at 6 weeks (p = 0.0005) and 12 weeks (p = 0.0001), writing at 6 weeks (p = 0.0001) and 12 weeks (p = 0.0003), and Archimedes spiral drawing at 6 weeks (p = 0.0006) and 12 weeks (p = 0.0002). More patients developed weakness after botulinum toxin treatment (42.2%) than after placebo injection (6.1%; (p = 0.0005). Weakness was mild (just detectable) to moderate (still able to use limb) and resolved within 2 weeks.

CONCLUSIONS: Targeted botulinum toxin type A injections significantly improve arm tremor and tremor-related disability in patients with MS. Classification of evidence: This study provides Class III evidence that targeted injection of botulinum toxin type A is associated with significant improvement in MS-related upper limb tremor. 



The conclusions say it all. BoTox inhibits nerve function and signalling and hence paralyses muscles for a period of time so this result could be expected. Search the blog for other uses in MS.This is good news as the treatment of tremor is a difficult task.

4 comments:

  1. This is something I need urgently. Can doctors start prescribing Botox for hand/arm tremors? Will neurologists administer it or will they refer you to someone else?
    I'm not in the UK so NHS/NICE/etc doesn't matter

    ReplyDelete
  2. Rachel Cook (LINK REMOVED) said...
    Truly a big concern! Generally we don't want to know the side (bad) affects of this kind of artificial application of beauty but it has few more and from these some is really dangerous like the above. So, we have to be more conscious about acquiring any beauty scheme. Thanks for a worthy explore.

    MENTION BOTOX and you get adverts like this slipping in with a link and a comment that really makes no sense

    ReplyDelete
  3. "MENTION BOTOX and you get adverts like this slipping in with a link and a comment that really makes no sense"

    You get the same when you mention CCSVI ;-)

    ReplyDelete
  4. Will neurologists administer it or will they refer you to someone else?

    Some neurologists are trained to do Botox injections, others will refer you to a Neuro-rehabilitation clinic.

    ReplyDelete

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