Oligodendroglial myelin basic protein (MBP) synthesis is essential for
myelin formation in the central nervous system. During oligodendrocyte
differentiation, MBP mRNA is kept in a translationally silenced state
while intracellularly transported, until neuron-derived signals initiate
localized MBP translation. Here we identify the small non-coding RNA
715 (sncRNA715) as an inhibitor of MBP translation. SncRNA715 localizes
to cytoplasmic granular structures and associates with MBP mRNA
transport granule components. We also detect increased levels of
sncRNA715 in demyelinated chronic human multiple sclerosis lesions, which contain MBP mRNA but lack MBP protein
DNA contains the genes and from DNA, there is RNA is transcribed which contains the coding sequence of proteins. The sequence of nucleotides is translated into the production of amio acids, which are then made into proteins. This is the case for all proteins including myelin proteins. This study shows that there is a non-coding piece of RNA and this inhibits the translation of MBP-related RNA into MBP protein. This is increases in demyelinated MS lesions and may serve to block myelination and importantly remyelination. Therefore blockade of this RNA may help lesions repair their myelin
Labels: Myelination