Epub: Zhou et al. Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro. PPAR Res. 2012;2012:145654.
Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis,
inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and
atherosclerosis. Recent findings suggest that enhanced activity of
interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an
important role in autoimmune diseases and inflammatory diseases.
In the present study, we hypothesized that fenofibrate (a synthetic ligand of peroxisome proliferator-activated receptor α (PPARα)) inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-β (TGF-β) and IL-6-induced differentiation of Th17 cells in vitro. However, other PPARα ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPARα independent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.
Yet another publication on Th17 cells. This study suggests that .fenofibrate could be of use in MS, but it is just hypothetical and much work would needs to be done to show it has any real value in MS.
CoI: None
In the present study, we hypothesized that fenofibrate (a synthetic ligand of peroxisome proliferator-activated receptor α (PPARα)) inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-β (TGF-β) and IL-6-induced differentiation of Th17 cells in vitro. However, other PPARα ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPARα independent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.
Yet another publication on Th17 cells. This study suggests that .fenofibrate could be of use in MS, but it is just hypothetical and much work would needs to be done to show it has any real value in MS.
CoI: None
http://youtu.be/dEbWrNL4_SY
ReplyDeleteAnon 8.29
ReplyDeleteProf G has posted this you tube post about Big Pharma Bribery Post.
Wish I was on the $1800 an hour?. However if pharma is using your skills or tapping your knowledge they should need to pay.
Exposed..medicine...weapons?
I think you should still trust your drug-pimping doctor
Pimp G HaHa:-) I guess we are his Hos
Please, just regard posts by Murray as based on sincere civil contributions, civil, and based on reason and referenced public evidence -- my area of knowledge since 1999 is aspartame methanol formaldehyde -- highly relevant is that formaldehyde modified brain cell proteins are potent triggers for immune system overreactions -- this is so basic that much MS research has been floundering for decades...
ReplyDeleteSorry posts by Murray are trolling spam. We want comments on current research not armchair science.
ReplyDeleteLearn something new...like politeness and stop posting this waffle. We have asked numerous times