Thursday, 6 September 2012

Stem Cell hype


Mesenchymal stem cells (MSCs) are multipotent cells that differentiate into the mesenchymal lineages of adipocytes, osteocytes and chondrocytes. MSCs can also transdifferentiate and thereby cross lineage barriers, differentiating for example into neurons under certain experimental conditions. MSCs have anti-proliferative, anti-inflammatory and anti-apoptotic effects on neurons. Therefore, MSCs were tested in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), for their effectiveness in modulating the pathogenic process in EAE to develop effective therapies for MS. The data in the literature have shown that MSCs can inhibit the functions of autoreactive T cells in EAE and that this immunomodulation can be neuroprotective. In addition, MSCs can rescue neural cells via a mechanism that is mediated by soluble factors, which provide a suitable environment for neuron regeneration, remyelination and cerebral blood flow improvement. In this review, we discuss the effectiveness of MSCs in modulating the immunopathogenic process and in providing neuroprotection in EAE.
 This is a review and we seldom post on reviews. This states "The data in the literature have shown that MSCs can inhibit the functions of autoreactive T cells in EAE and that this immunomodulation can be neuroprotective. In addition, MSCs can rescue neural cells via a mechanism that is mediated by soluble factors, which provide a suitable environment for neuron regeneration, remyelination and cerebral blood flow improvement". I disagree there is very little in the literature to suggest that MSC do anything other than immunosuppression/immunomodualtion the production of neurons and myelin is extremely scant. This feeds the hype.

5 comments:

  1. In Tuesday's Telegraph there was an article reporting findings of a team from Zurich univ. that had been presented at the conference of the International Spinal Cord Society in London on Monday. Using stem cells in an initial trial, 2 out of 3 men had regained sensation below the level of the break in their spine. Do you know anything about this?

    ReplyDelete
  2. prof curt not as optimistic as dr huhn;us firm geron pulled out of similar trial because of cost concerns. on msrc site see stellas hsct blog...............similarish. long way to go still...............

    ReplyDelete
  3. The Ms Soc FB page run a couple of articles / videos with ref to stem cell treatment. It looked very promising, they were saying confidently 10 to 15 years, lets hope so especially for the pw ppms.

    ReplyDelete
  4. Stella's blog was following a SC transplant. I don't think this trial was for transplant, just some form of treatment. There is a company involved StemCell Inc. so maybe it's fishing to get funds for phase 2/3 trials.

    ReplyDelete

Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.