Sunday, 11 November 2012

Research: Japenese bladders respond to botox too

Epub: Hikita et al. Botulinum toxin type A injection for neurogenic detrusor overactivity: clinical outcome in Japanese patients. Int J Urol. 2012 Nov 6. doi: 10.1111/j.1442-2042.2012.03218.x.

To report our experience with intravesical injection of botulinum toxin type A into the detrusor muscle of patients with neurogenic detrusor overactivity secondary to suprasacral spinal cord lesions or multiple sclerosis.


METHODSBetween January 2003 and March 2011, 11 patients (aged 23-75 years) were treated with 40 injections of botulinum toxin type A 300 U. The patients were followed up for 4, 8 and 12 weeks after treatment. The King's Health Questionnaire was administered and cystometric studies were carried out at baseline and 8 weeks after treatment.

RESULTSA total of six women and five men were treated. Analysis of the King's Health Questionnaire showed a significant improvement in eight of the nine domain scores at 8 weeks from baseline. On cystometric studies, the mean maximum cystometric capacity increased significantly in all patients at 8 weeks from baseline (P < 0.001). Bladder compliance also increased significantly (P < 0.001). The number of urinary incontinence episodes per day improved significantly from baseline after injection (4 weeks, P < 0.001; 8 weeks, P < 0.001; 12 weeks, P < 0.001). Lack of efficacy appeared 7.15 ± 3.4 months after treatment.

CONCLUSIONSInjection of botulinum toxin type A into the detrusor muscle of patients with neurogenic detrusor overactivity secondary to suprasacral spinal cord lesions or multiple sclerosis consistently improves bladder control and quality of life



This study shows that Japenese MSer bladders respond positively to BoTox just like other MSers bladders do.

2 comments:

  1. I had no doubt about this and it's great that botox proved once again its effectiveness.
    In Ottawa botox for bladders is a very popular treatment because people understood this is the most effective way to treat this problem.
    Hopefully scientists will find a longer lasting version of botox because that would definitely make many people happy.

    ReplyDelete
  2. if that is true, then more of botox secrets are to be revealed.

    houston botox

    ReplyDelete

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