Thursday, 29 November 2012

Research: Measuring Fatigue

Epub: Yu et al. A wireless body measurement system to study fatigue in multiple sclerosis. Physiol Meas. 2012;33(12):2033-2048. 

Fatigue is reported as the most common symptom by patients with multiple sclerosis (MS). The physiological and functional parameters related to fatigue in MS patients are currently not well established. A new wearable wireless body measurement system, named Fatigue Monitoring System (FAMOS), was developed to study fatigue in MS. It can continuously measure electrocardiogram, body-skin temperature, electromyogram and motions of feet. The goal of this study is to test the ability of distinguishing fatigued MS patients from healthy subjects by the use of FAMOS. This paper presents the realization of the measurement system including the design of both hardware and dedicated signal processing algorithms. Twenty-six participants including 17 MS patients with fatigue and 9 sex- and age-matched healthy controls were included in the study for continuous 24 h monitoring. The preliminary results show significant differences between fatigued MS patients and healthy controls. In conclusion, the FAMOS enables continuous data acquisition and estimation of multiple physiological and functional parameters. It provides a new, flexible and objective approach to study fatigue in MS, which can distinguish between fatigued MS patients and healthy controls. The usability and reliability of the FAMOS should however be further improved and validated through larger clinical trials.

Get the system improved so that it is an available tool to measure fatigue, which is very high on the list of problems with MS, but very under investigated. However, with tools to monitor are a step towards being able to treat. Part of the slowness in progress in MS is the lack of responsive outcomes


  1. Chronic fatigue cut short my business career in my 30s, taking with it my financial security and potential. Twenty-some years later, I cannot recall what it feels like to function without fatigue's fog. Sadly, the fatigue feels "normal."

  2. I have been diagnosed with Multiple Sclerosis. The diagnosis was made here in Berlin 5 and a half years ago.I was 34 years old at the time and had 2 children. I now have three children. I often feel very tired -indeed fatigued. I tend to think this is due to the intensive demands of motherhood, night interruptions etc and don't think I differ from other mothers in my age-group at all. One thing I have noticed and I believe this is due to MS - I cannot jog more than 3km any more (I used to run half marathons and until about a year ago, enjoyed up to 7km runs.) I also do notice and have noticed for many years, cognitive impairment and real difficulty to concentrate myself on subjects, even those that really interest me.Short bursts of sport really help this temporarily.



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