Friday, 21 December 2012

Vitamin D slows down development of MS in CIS

Epub: Derakhshandi et al. Preventive effect of vitamin D3 supplementation on conversion of optic neuritis to clinically definite multiple sclerosis: a double blind, randomized, placebo-controlled pilot clinical trial. Acta Neurol Belg. 2012 Dec.

Multiple sclerosis (MS) presents with optic neuritis (ON) in 20 % of cases and 50 % of ON patients develop MS within 15 years. In this study, we evaluated the preventive effects of vitamin D3 administration on the conversion of ON to MS (primary outcome) and on the MRI lesions (secondary outcome) of ON patients with low serum 25 (OH) D levels. Thirty ON patients (15 in each of 2 groups, aged 20-40 years) with serum 25 (OH) D levels of less than 30 ng/ml were enrolled in a double blind, randomized, parallel-group trial. The treatment group (cases) received 50,000 IU of vitamin D3 weekly for 12 months and the control group (controls) received a placebo weekly for 12 months. Finally, the subsequent relapse rate and changes in MRI plaques were compared between the two groups. Risk reduction was 68.4 % for the primary outcome in the treatment group (relative risk = 0.316, p = 0.007). After 12 months, patients in the treatment group had a significantly lower incidence rate of cortical, juxtacortical, corpus callosal, new T2, new gadolinium-enhancing lesions and black holes. The mean number of total plaques showed a marginally significant decrease in the group receiving vitamin D3 supplementation as compared with the placebo group (p = 0.092). Administration of vitamin D3 supplements to ON patients with low serum vitamin 25 (OH) D levels may delay the onset of a second clinical attack and the subsequent conversion to MS.



 Make this one of your 5 a day. But you need to take enough!

Well well, this surprises me and maybe this nutriceutical is going to make a greater impact than I thought. This study treats CISers and gives them Vitamin D or placebo and it seems that there was a reduction in the rate of MS developing. This is good news. Something for MS that is not going to break the bank. But one point mean number of total plaques showed NO decrease in the group receiving vitamin D3 supplementation. p = 0.092 is NOT statisitically significant, is it biologicallysignificant?

The study was quite small and so it remains to be seen if it will be substantiated however, I am aware of a similar study occuring in the Netherlands.


Prof G may want to comment more on this study as it is his thing. 

9 comments:

  1. Vit D is not a nutraceutical
    That aside, 5000 units a day are recommended for all MSers. I will never agree to a study where you have to forgo this and risk having a worse disease course and don't how anyone will agree

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  2. Anybody coming to this blog without prior knowledge, and seeing the advent calendar (especially Brunhilda' moustache) etc will think you're all completely bonkers!! Merry Christmas :-)

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    1. We are completely bonkers, that's what a career in research does to you.
      Merry Christmas and a great New Year to you too ;-)

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    2. Utes mum had a laugh got a text from germany

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  3. Please remind me how many ius of vit D you recommend/suggest, and do you recommend calcium supplements at the same time, for any section of the population? Thanks

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    1. Prof g will answer this but be careful with calcium supplements.

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  4. what posts you are putting on is NOT GOOD AT ALL .NOT one of you know what you are doing SO UMPROFESSIONAL

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    1. Exactly my thought and while I´m at it a Happy New Year!!!
      //Sara

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