Wednesday, 30 January 2013

CCSVI Research: Now Pigs! Should we save them for bacon?

EpubHabib et al. MR imaging of the yucatan pig head and neck vasculature. J Magn Reson Imaging. 2013 Jan 24. doi: 10.1002/jmri.24003.
 

PURPOSE: To evaluate the cerebral venous drainage system of the swine as a probable model to test whether extracranial venous abnormalities may play a role in neurodegenerative diseases as reported recently in multiple sclerosis.

MATERIALS AND METHODS: Three Yucatan micropigs, 5 to 7 months old, were scanned with a comprehensive MRI protocol at 3 Tesla. The vascular anatomy of the head and neck was imaged using conventional and angiographic MR sequences. Phase-contrast MR images were collected at multiple levels of the neck and intracranial space to monitor flow.


RESULTS: Three large cervical veins were observed; the external jugular vein draining the olfactory and gustatory tissues; the internal jugular vein (IJV) draining the cavernous sinus as well as surrounding soft tissues in the neck; and the ventral vertebral venous plexus (VVVP) surrounding the dural sac and paraspinal region. The majority of the cerebral blood flow in the pig appears to drain through the VVVP. Flow through the IJV comprised a nondominant component. Anastamoses were observed connecting the major veins of the neck bilaterally.


CONCLUSION: The dominance of outflow from the brain to the VVVP may be analogous to the typical dominance of the IJVs in humans in the supine position.




First we had mice.....next pigs for animal experiments? Do we need research in this area?, if so should we study animals? or should we concentrate on humans?

Given the recent Italian study on the lack of good indications for efficacy of venoplasty maybe we should Save the Pigs. 

I suspect their use in food will be far more useful.

1 comment:

  1. I did not know how else to respond to your post about pigs and CCSVI,almost like you don't want a response. Yes most definitely start phase III trials on humans now. Spare the animals and us having to wait for relief from symptoms you can;t begin to understand.

    This was email sent on this post, In terms of response, we turn comments off on CCSVI posts as we take too much abuse and it is is not good for our other readers

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