Friday, 18 January 2013

Research: Snuff use and MS

EpubHedström, et al. Nicotine might have a protective effect in the etiology of multiple sclerosis. Mult Scler. 2013 Jan

Objective: The use of moist snuff is common in Sweden and leads to exposure to high doses of nicotine. Recent studies indicate that exposure to nicotine could modulate immune responses. The aim of this study was to investigate the influence of snuff use on the risk of developing multiple sclerosis (MS), taking smoking habits into consideration.

Methods: In two Swedish population-based, case-control studies (7883 cases, 9437 controls), subjects with different snuff use habits were compared regarding MS risk, by calculating odds ratios (ORs) with 95% confidence intervals (CIs).

Results: Snuff-takers have a decreased risk of developing MS compared with those who have never used moist snuff (OR 0.83, 95% CI 0.75-0.92), and we found clear evidence of an inverse dose-response correlation between cumulative dose of snuff use and the risk of developing the disease. We further observed that subjects who combined smoking and snuff use had a significantly lower risk for MS than smokers who had never used moist snuff, also after adjustment for amount of smoking.

Conclusions: Our results add evidence to the hypothesis that nicotine exerts anti-inflammatory and immune-modulating effects in a way that might decrease the risk of developing MS.

Swedish Snuff is not snorted like British Snuff, but it (Snug) is placed around the Gum

This study provides somewhat surprising results! It has been well-established that smoking is associated with an increased risk of MS, and this group have previously shown that this increased risk is not present in those who use snuff/chewing tobacco. We don't yet know why smoking appears to increase MS risk, and this study hints that it might be the route of delivery (i.e. tobacco smoke in the lungs) that is important. There is clearly more work to be done here to better understand this.

However, this is not a reason to start chewing tobacco - this has been associated with an increased risk of cancer in the same way that smoking is: http://www.cancer.gov/cancertopics/factsheet/Tobacco/smokeless

8 comments:

  1. Smoking causes MS or does having MS cause to smoke, that is the question.

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  2. so the lungs seem to provide a clue not tobacco methinks.

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  3. This is so stupid. It once again confirms how far away we are from unravelling the causes of MS. Just fishing in the dark.

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  4. Since I am in the process of quitting it will be interesting to know if using nicotine skin patches will have a beneficial anti-inflammatory response! Bonus!!!!

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  5. During migraines I look for ways to make myself sneeze. It gives a momentary respite

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  6. Smoking and MS @AnonymousFriday, January 18, 2013 10:33:00 am and ProfG

    Anonymous raised a very interesting question and I would give you my POV which is mostly based on analyzing data of food, tabacco smoke, studies at hospitals etc. pp.

    1st.: I noticed that my need for smoke is lower when I take a potassium supplement before I go to the hospital and get my methylprednisolon infusions (potassium aspartat or a a magensium/pottassium supplement)

    2nd: I noticed (very subjective notice) that the amount of smokers having MS is higher than the normal healthy ppl (50/50 to 70/30 in MSers, based on stuides.

    3rd: I analyzed the data of tabacco smoke. Tabacco smoke has around 70mg / cig. of potassium as cation (value is based on data of e.g. Römpp Lexikon Chemie ISBN 3-440-04516-1 and other sources)

    4th: Potassium levels seems to be affected in ppl with MS

    5th: my smoking habit is not constant (never was) I smoked none to 20 cigs / day and around none to 8 since the last 3 years while taking potassium supplements.

    Hypothesis:

    Smoking is a kind of "marker" for MS. Dropping potassium levels correlate in some way with smoking, as 20 cig /day provide the body with around 1400mg of potassium!!! in a cation form, which can be absorbed quite well by the mucous membranes of the mouth and nose (maybe even in the lung??)
    The negative aspects (toxic ingredients) have side effects and are not beneficial at all.

    To be verified.

    Idea: create a smoking liquid containing potassium and sell them for e-cigarettes, so smokers can have the smoke feeling and still have their potassium intake.

    I think you have more and better data on potassium levels and smoking behaviours.

    English is not my mother tongue, I hope the hypothesis above can be understand.

    Regards

    Marc (™)

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  7. Nicotine down-regulates IL-17 that's probably the mechanism. Look for new drugs that are developed to mimic this action, see: http://www.nature.com/nrd/journal/v11/n10/fig_tab/nrd3794_T1.html

    You're welcome.

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    Replies
    1. Therefore smoking (plenty of nicotine) should suppress MS, but it seems the opposite.

      Science is a sea of contradiction or maybe it is not always simple.

      Delete

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