Monday, 15 April 2013

Research Cognitive Reserve

Do you have adequate cognitive reserve? #MSBlog #MSResearch

Epub: Amato et al. Cognitive reserve and cortical atrophy in multiple sclerosis: A longitudinal study. Neurology. 2013 Apr 10.

OBJECTIVE: To test the cognitive reserve (CR) hypothesis in the model of multiple sclerosis (MS) by assessing the interactions among CR, brain atrophy, and cognitive efficiency in patients with relapsing-remitting MS.

METHODS: A Cognitive Reserve Index was calculated including education, leisure activities before disease, and IQ. Brain atrophy was assessed through magnetic resonance quantitative parameters of normalized total brain volume and normalized cortical volume. Cognitive function was measured using Rao's Brief Repeatable Battery.

RESULTS: Fifty-two patients with relapsing-remitting MS were evaluated at baseline and 35 of them were reassessed after a 1.6-year follow-up period. At baseline, higher CR predicted better performance on most of the Brief Repeatable Battery tests, independent of brain atrophy and clinical and demographic characteristics (p ≤ 0.021). An interaction between CR and normalized cortical volume predicted better cognitive performance on tasks of verbal memory and attention/information processing speed (p < 0.005). However, at the follow-up examination, progressing cortical atrophy (p = 0.008) and older age (p = 0.044) were the only predictors of deteriorating cognitive performance.

CONCLUSIONS: Our findings suggest that higher CR in individuals with MS may mediate between cognitive performance and brain pathology. CR-related compensation may, however, fail with progression of damage. The time window of opportunity for therapeutic approaches aimed at intellectual enhancement most likely lies in the earliest disease stages.



The concept of cognitive reserve (CR) emerged from studies on Alzheimer disease (AD) that revealed that individuals with greater CR were less likely to show cognitive decline as AD pathology accumulated. Cognitive reserve has typically been defined as spare cognitive capacity available to buffer the effects of disease or trauma to the brain. This study suggests "use it or lose it" and that people with more CR do better. It suggests that methods to try an increase cognitive reserve should be stated early because as brain volume is lost so is cognitive performance.

4 comments:

  1. Very interesting,

    "This study suggests "use it or loose it" and that people with more CR do better."

    Any ideas how can one add to ones reserve?

    Is passive intellectual stimuli (reading, debating...) enough or shall we immerse our self into a more active form (joining a chess club)?

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    Replies
    1. I would imaging passive intellectual stimuli are similar to more active one but where is the research to back this up

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  2. Very disheartening for pediatric MS. MS happens before cognitive reserve is built.

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    Replies
    1. However, the repair potential may be better in younger rather than older people

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