Thursday, 16 May 2013

Should Project VD be Project M?

Epub: Golan et al. The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis. Brain Behav Immun. 2013 May 7.

BACKGROUND: MS incidence is higher in geographic regions with less sunlight exposure. Both vitamin D and melatonin are essential mediators of the effect of sunlight in health, and as such are candidates to play a key role in MS. We hypothesized that vitamin D and melatonin may have related influences in patients with MS.


METHODS: In a randomized, double blind study of 40 IFN-β treated MS patients, 21 patients were assigned to 800 IU of vitamin D3 per day (low dose), while 19 patients received 4,370 IU vitamin D3 per day (high dose) for one year. Serum 25-hydroxy-vitamin-D (25-OH-D) and night time urine melatonin metabolite, 6-sulphatoxy-melatonin (6-SMT), were measured at baseline, 3 months and 1 year from enrolment.


RESULTS: After 3 months supplementation, 25-OH-D levels increased and night-time melatonin secretion decreased significantly in the high dose group, but not in the low dose group. After 1 year, a decrease in 25-OH-D levels, accompanied by an increase of urine nighttime 6-SMT were observed in the high dose group. Percent change in serum 25-OH-D was significantly and negatively correlated with percent change in urine 6-SMT after 3 months and between 3 months to 1 year. 25-OH-D levels by the end of the study were significantly and negatively correlated to BMI.


CONCLUSIONS: Melatonin secretion is negatively correlated with alterations in serum 25-OH-D in IFN-β treated patients with MS. The finding suggests that melatonin should be considered as a potential mediator of vitamin D neuro-immunomodulatory effects in patients with MS.




We have been of the Vitamin D crusade or should I say Prof G, DoctorRuth and Ram have been crusading, this project looks at the influence of vitamin D on the production of melatonin, a chemical produced that influences night-day cycles and sleep....and is part of my Jet Lag ritual.

Could this be the...or a...mediator of the vitamin D effects as there is some modest evidence to sugggest a role in immune function?.

Melatonin is another nutriceutical not in the chemists in UK but I get my fix for a few bucks, when in the States.

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