Friday, 7 June 2013

Australian MSers have MS Genes just like European MSers

Qiu et al. The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort. J Neuroimmunol. 2013. doi:pii: S0165-5728(13)00119-7.

Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/CD58, CLEC-16A/CTLA-4, and TYK2/IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups.


This study shows that many of the genes associated with MS Susceptibility in European MSers also can be found in Australian MSers, which I guess is to be expected. But indicates that the geneticists have something that they need to explain the biology of. 

4 comments:

  1. The 'Viking Gene' ?

    Regards as always.

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    Replies
    1. No, way. Iran has a huge number of MSers AND IS NOWHERE NEAR Scandinavia and was never invaded by Saxons.

      I am, however, willing to accept that Arian tribes are at the epicentre of MS because they cam from central Asia and shifted to north Europe and to south Asia, including Persia. That Is why the swastika is a potent symbol, both culturally and spiritually. The Arian race is the carrier of MS genes.

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    2. I think Iranian MS has a lot to do with vitamin D deficiency over the last 30 years or so.

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    3. The 'Viking Gene'? No the petty criminal gene!

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