Sunday, 2 February 2014

Papers for old Prozac.

Prozac for progressive MS. #MSBlog #MSResearch

Epub: Cambron M et al..Fluoxetine in Progressive Multiple Sclerosis (FLUOX-PMS): study protocol for a randomized controlled trial. Trials. 2014; 15:37.

BACKGROUND: Fluoxetine might theoretically reduce axonal degeneration in MS because it stimulates energy metabolism through enhancing glycogenolysis*, stimulates the production of brain-derived neurotrophic factor**, and dilates cerebral arterioles. The current document presents the protocol of a clinical trial to test the hypothesis that fluoxetine slows down the progressive phase of MS.

glycogenolysis = is the breakdown of glycogen to release glucose a sugar the brain uses as it main source of energy

brain-derived neurotrophic factor (BDNF) = is a growth factor. BDNF acts on certain neurons of the central and peripheral nervous system  helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. Synapses are the connections between neurones; they convert an electrical into a chemical signal. 

METHODS: The FLUOX-PMS trial is a multi-center, randomized, controlled and double-blind clinical study. A total of 120 patients with the diagnosis of either secondary or primary progressive MS will be treated either by fluoxetine (40 mg daily) or placebo for a total period of 108 weeks. 

DISCUSSION: The FLUOX-PMS trial will gives us information as to whether fluoxetine has neuroprotective effects in patients with progressive MS.Trial Registration: Eudra-CT: 2011-003775-11.


A new way for Neuros to get publications is to tell us what they are going to do, when you are only interested to know what was done and found. The difference between the two is a number of years Maybe scientists should start a journal and call it "Experiment". However they may get scooped. Someone else may do it quicker.

Anyway, as you say not enough is being done about progressive MS, I thought I would post about this.

Fluoxetine is frequently used to treat major depression and is an SSRI selective serotonin re-uptake inhibitor also known as Prozac this follows on from earlier studies in less than 50 MSers where it was suggested that "at least 200 patients would have been needed to detect a 50% treatment effect so is this study adequately powered. It is suggested that fluoxetine stimulates astrocytic glycogenolysis, which serves as an energy source for axons, may be good thing to do, let's hope so.


5 comments:

  1. What is glycogenolysis? What is brain-derived neurotrophic factor? Your posts are becoming very difficult to follow.

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    1. Done; I have included definitions of the terms in the post.

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  2. Sorry for not adding links to technical terms.Hopefully I will have more time to do posts soon.

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  3. Mouse, you say there is not enough being done about progressive MS, well PPMS case in point. Look at the UCLP trials, there isn't one (other than STREAMS with highly, highly selective criteria) which is open to that cohort of progressive MSers. It's beyond depressing knowing that if you are cursed with this disease you are left to rot. No one wants to help and no one cares, would you be content with the wait for clinical trials line if you knew that there aren't really any likely effective ones on the horizon?
    There really is no hope..
    Even if there are no approved treatments is there anything we can try???

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    Replies
    1. we have three trial on the go look at the DE-FLAMES2 info graphic

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