IL-1 linking into damage

Seppi D, Puthenparampil M, Federle L, Ruggero S, Toffanin E, Rinaldi F, Perini P, Gallo P. Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset. J Neuroimmunol. 2014 Mar 6. pii: S0165-5728(14)00064-2. doi: 10.1016/j.jneuroim.2014.02.014. [Epub ahead of print]

The cerebrospinal fluid levels of interleukin-1 beta and structural magnetic resonance parameters of cortical damage, i.e., cortical lesion number and volume, and global cortical thickness, were analysed in multiple sclerosis patients at clinical onset. Cerebrospinal fluid interleukin-1 beta levels strongly correlated with cortical lesion load and cortical thickness, while correlation with white matter lesion load was modest. Interleukin-1 beta, intrathecally produced by infiltrating lymphocytes and activated microglia, may constitute a possible link between inflammation and neurodegeneration in multiple sclerosis.

We have recently heard of the suggestion that IL-1 may be a maker of future progression here it is a marker of current damage

as has been suggested previously. Here it is suggested that it may linked to cortical problems, which means that there may be problems in cognition.