Saturday, 19 April 2014

Pregnancy and Drugs

Beaber et al. Immunomodulatory agents and risk of postpartum multiple sclerosis relapses. Perm J. 2014 ;18(1):9-13. doi: 10.7812/TPP/13-090.

Of 80 women who breastfed little or not at all, 55 (69%) resumed treatment for multiple sclerosis within 1 year post-partum, of whom 26 (47%) relapsed within 6 months post-partum. Later in the post-partum year, those who resumed treatment early had fewer relapses. Starting treatment with interferon beta or glatiramer acetate within 2 weeks post-partum does not reduce the risk of post-partum relapse of multiple sclerosis but may reduce the risk of subsequent relapses in the post-partum year.



You can read the conclusions. Read through the blog for pregnancy advice by ProfG.

30 Jan 2014
Therefore pregnancy is an important consideration when it comes to choosing a DMT. All the current DMTs have issues with pregnancy; woman are not meant to fall pregnant on DMTs due to risk of teratogenicity (ability of a ...
26 Jul 2013
Methods: The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons ...
25 Oct 2012
METHODS: They recruited MSers, prospectively followed-up in 21 Italian MS Centres, for whom a pregnancy was recorded in the period 2002--2008. MSers were divided into 2 groups: drug-exposed pregnancies (EP: ...

02 May 2013
OBJECTIVES: The objectives of this research are to prospectively evaluate the prevalence of thyroid autoimmunity among MSers in relation to pregnancy, and to investigate its impact on pregnancy outcome, postpartum ...
14 Aug 2012
Conclusion: Although the course of MS was deteriorated 3 months after delivery, it was not statistically significant comparing annual relapsing rates during the years prior to pregnancy. Moreover, the rate of disease ...
02 Jun 2013
Objective: The analysis of perinatal results in pregnant women with multiple sclerosis (MS) and the assessment of the influence of pregnancy on this chronic disease in the population of pregnant women in our hospital in the ...
09 Mar 2013
"I am often asked what topics are neglected in MS research, that are very important for MSers? Pregnancy is one of these areas. Therefore it is very appropriate that ECTRIMS has just sponsored a focused workshop on this ...

24 Jun 2013
The majority of NDMSC respondents (72.5%) and NARCOMS subset (75.2% females), did not encounter a pregnancy following diagnosis of MS. The most common MS-related reason for this decision was "symptoms ...
14 Apr 2012
The investigators reviewed medical records and used a structured questionnaire to investigate gravidity (number of pregnancies), parity (number of births), and the number of relapses during the 2 years before pregnancy, ...
15 Jul 2011
The average or mean rate of relapse was 0.7 per year in the year before pregnancy, 0.5 during the first trimester, 0.6 during the second trimester and 0.2 during the third. The rate increased to 1.2 during the first three months ...
28 Jul 2011
Methods: In 2001, 35,794 mothers of participants of the Nurses' Health Study II completed a questionnaire inquiring about their experiences and diet during pregnancy with their nurse daughters. This allowed these ...

11 Mar 2013
"As you are aware pregnancy affects the natural history of MS; what are the mechanisms that underlie these effects? If we can define them we may be able to mimic a state of pregnancy, i.e. pseudopregnancy, and use this to ...
16 Jul 2011
"Because of this study, and the fact that pregnancy itself reduces the attack rate, researcher's have been trying to find out what it is about pregnancy that is so beneficial for MS'ers." "We assume that the profound changes that ...
16 Sep 2011
Background: The incidence of disease-modifying drug (DMD) exposure during pregnancy in MS'ers is unknown and limited data exists regarding the potential harm of DMD exposure during pregnancy. Objective: To ...
31 May 2011
Of the women exposed to natalizumab during pregnancy, 29 women gave birth to 28 healthy children; one child was born with hexadactyly (an extra finger), 5 pregnancies ended in an early miscarriage and one woman ...

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