Monday, 2 June 2014

High Blood Lipids, make sure they are controlled.

Tettey P, Simpson S Jr, Taylor B, Blizzard L, Ponsonby AL, Dwyer T, Kostner K, van der Mei I.vvAn adverse lipid profile is associated with disability and progression in disability, in people with MS. Mult Scler. 2014 May. pii: 1352458514533162. [Epub ahead of print]

There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis(MS).
OBJECTIVES:To investigate the associations between serum lipids, apolipoproteins and disability in MS.
METHODS:A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002 - 2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression.
RESULTS:In the unadjusted analyses, nearly all lipid-related variables were positively associated with Expanded Disability Status Scale (EDSS). After adjustment for confounders, total cholesterol (TC) (p = 0.037), apolipoprotein B (ApoB) (p = 0.003), and the apolipoprotein B to apolipoprotein A-I ratio (ApoB/ApoA-I ratio) (p = 0.018) were independently associated with a higher EDSS. Higher body mass index (BMI) was also independently associated with higher EDSS (p = 0.013). With the progression analysis, the total cholesterol to high density lipoprotein (HDL) ratio (TC/HDL ratio) (p = 0.029) was prospectively associated with subsequent change in EDSS.
CONCLUSION:In this prospective population-based cohort study, an adverse lipid profile was associated with high levels of MS disability and disease progression. Improving serum lipids may be beneficial for MS patients, to potentially improve clinical outcomes and vascular comorbidities.

So people with higher blood lipids did worse, so improving them may be beneficial, is this how statins (Choare having a beneficial effect for MS?

3 comments:

  1. Could this, together with high Omega 3 intake and High vit D levels be why diets such as OMS etc have good results?

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  2. Does this establish a link between diet and MS and wouldn't that be a very important finding?
    Most neurologists have always said there is no such link

    What are the possible causes for this association?

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  3. I think the emerging link between lipids (artheroscerosis) and MS is a sound one based on my long observations - of course, one still needs a genetic predisposition for MS but in people who have a tendency for high levels of lipids in blood reducing them either by diet or statins brings benefits.

    I observed in myself that during and after a relapse I tend to eat fish up to four times a week and have appetite for other 'healthy' fats like oils, nuts.

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