Sunday, 8 June 2014

Is EAE a bad disease in your Eyes

The UK Government want to get rid of experiments that cause a lot of suffering to animals, but want treatments for dementias that cause a lot of suffering to humans. EAE is one of those diseases considered to be bad


However, they want us to be be open about animal experiments. UK researchers are far from open..they have a fear of the militatnt anti-vivisectionis, but in the US there is is a grater acceptance of animal studies. So we have EAE work on stem cells in USA Today.



The healthier-looking mouse received a stem cell treatment for its multiple sclerosis-like symptoms, while the mouse lying down did not.

Would I publish a picture like this...unlikely..because without context it looks pretty grim and one can ask is it necessary for the mouse to get to this sorry state.

What do you you think? 

If you want to see what EAE can look like have a look at the video on the website (CLICK HERE)

8 comments:

  1. It doesn't shock me in the same way as seeing young adults in care homes because of MS, or knowing a 22 years ol woman with SPMS - in a wheelchair, unemployed, no future. I've had MS for over a decade. EAE has not helped me one bit. The basic questions relating to MS won't be answered by MS. EAE is not MS, it is an industry created by the academics to keep the grants flowing. If experiments on kice relating to EAE / mic stopped tomorrow, the lives of MSers wouldn't be affected. I'm guessing that mice do get some diseases which humans get, so experiments / research are justified. Mice do not get MS. If the Charcot project is sucessful and MS can be controlled by anti-retro viral drugs (as the underlying cause is EBV) will you stop EAE experiments? I know this has been your work for the last 20 years, but is academic work not what I need. A survey 'has EAE had a beneficial affect on your disease' is likley to get a negative response. There is a claim that EAE work led to Tysabri, but I didn't see EaEologists identifying PML as an issue.

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  2. Kill/ torture whatever animals you need to. If it stops me getting progressive MS then I'm all for it.

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    1. Maybe I will quote you when hauled up before the Home Office:-)

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  3. I did not see EAEologists identifying PML as an issue.

    (a) Animals are kept in virus/pathogen free conditions, but it does not take a rocket scientist to think that if you remove large parts of your immune system that you will be at risk to infections.
    (b) EAE experiments are done over a few weeks and not a few years which is where the risk of PML becomes more apparent
    (c) A rare event is not going to be picked up. Even high risk PML is about 1% few animal experiments contain 100 animals.
    (d) The neurologists did not predict this either

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    1. If academic work stopped tomorrow the lives of MSers would not be affected, but in time maybe. You have to remember it takes 10-15 years for discoveries to filter through.

      If the Charcot project is successful will we stop EAE, maybe some aspects, but even if Charcot is succesfull there maybe other questions..maybe we just move on time will tell.

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  4. To AnonymousSunday, June 08, 2014 8:17:00 am,

    What treatments are you on or which ones have you tried and "failed"?

    Personally I am glad that Copaxone was derived from EAE as it has stabilized my disease. This is also the case for thousands of other MSers and is clear from the longterm follow-up studies:

    http://www.ncbi.nlm.nih.gov/pubmed/20106943

    It is not a cure, but it has made MS live able for many. If you are putting all of your eggs in the Chariot Project basket, I'm afraid this is a bit hopeful. If it does show efficacy, you first have to identify who will need this therapy PRIOR to acquiring ms. Identifying those that will be afflicted with MS is the most important aspect that is needed now.

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    1. you have to identify who will need therapy PRIOR...
      If this is the case then charcot fails as people in charcot trial have MS

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    2. Well, Anon may be under the impression that the Charcot Project is going to control MS because they believe EBV is the cause of the disease. So if the Charcot Project results in the halting of disease in 100% of msers then you potentially have a cure if you can identify those that wiil be afflicted by MS in the future. We shall see what results.

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