Sunday, 20 July 2014

Spasticity is associated with walking problems

Balantrapu S, Sosnoff JJ, Pula JH, Sandroff BM, Motl RW. Leg spasticity and ambulation in multiple sclerosis. Mult Scler Int. 2014;2014:649390. doi: 10.1155/2014/649390.

Background. Spasticity of the legs is common in multiple sclerosis (MS), but there has been limited research examining its association with ambulatory outcomes. 
Objective. This study examined spasticity of the legs and its association with multiple measures of ambulation in persons with MS. 
Methods. The sample included 84 patients with MS. Spasticity of the legs was measured using a 5-point rating scale ranging between 0 (normal) and 4 (contracted). Patients completed the 6-minute walk (6 MW), timed 25 foot walk (T25FW), and timed up-and-go (TUG), and O2 cost of walking was measured during the 6 MW. The patients undertook two walking trials on a GAITRite (CIR systems, Inc.) for measuring spatial and temporal parameters of gait. The patients completed the Multiple Sclerosis Walking Scale-12 (MSWS-12) and wore an accelerometer over a seven-day period. 
Results. 52% (n = 44) of the sample presented with spasticity of the legs. Those with leg spasticity had significantly worse ambulation as measured by 6 MW (P = 0.0001, d = -0.86), T25FW (P = 0.003, d = 0.72), TUG (P = 0.001, d = 0.84), MSWS-12 (P = 0.0001, d = 1.09), O2 cost of walking (P = 0.001, d = 0.75), average steps/day (P < 0.05, d = -0.45), and walking velocity (P < 0.05, d = -0.53) and cadence (P < 0.05, d = -0.46). 
Conclusion. Leg spasticity was associated with impairments in ambulation, including alterations in spatiotemporal parameters and free-living walking
This rather self-explanatory. If you have limb spasticity it may be associated with walking problems

CoI: TeamG are trying to develop anti-spastics


  1. CoI: TeamG are trying to develop anti-spastics

    Seems very cruel - my best friend has cerebral palsy

    1. You are being too sensitive?
      Ant-spastics = agents/drugs that inhibit spasms and spasticity

  2. Why do research funders allow research like this. I can see the need for replicating results, but this is duplication gone made. This sort of research is just a statement of the obvious and the results have been verified in huge numbers of research pieces. Only research which provides new insights should be funded.

    1. Many don't, for much clinical research you don't really need alot of funding


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