Saturday, 19 July 2014

Vitamin D birth levels do not affect risk of MS

Ueda P, Rafatnia F, Bäärnhielm M, Fröbom R, Korzunowicz G, Lönnerbro R, Hedström AK, Eyles D, Olsson T, Alfredsson L. Neonatal vitamin D status and risk of multiple sclerosis.
Ann Neurol. 2014 Jul. doi: 10.1002/ana.24210

Objective: Low vitamin D status at birth may be associated with risk of adult onset multiple sclerosis, but this link has not been studied directly. We assessed the relation between neonatal vitamin D concentrations, measured in stored blood samples, and risk of multiple sclerosis. 

Methods: This was a population-based case-control study in Sweden including 459 incident cases of multiple sclerosis and 663 controls, randomly drawn from a national population registry and frequency matched on sex, age and residential area. 
Results: There was no association between neonatal 25-hydroxyvitamin D quintile and risk of multiple sclerosis (crude odds ratio 1.0, 95% confidence interval 0.68 to 1.44, for the highest quintile compared to the lowest). Adjusting for a number of potential confounding factors in early life (month of birth, latitude of birth, breastfeeding) and in adult life (25-hydroxyvitamin D, sun exposure, vitamin D intake from dairy products, fat fish consumption, smoking, body mass index at 20 years of age) as well as ancestry, multiple sclerosis heredity, and socioeconomic group, did not considerably affect the result. 
Interpretation: At a broad population level, 25-hydroxyvitamin D at birth was not associated with risk of multiple sclerosis.

This study looks at vitamin D levels at birth and then follows the risk to see what the risk of MS is and they did not find a risk.  Maybe ProfG will comment on this it is his baby, should it be thrown out with the bath water. I suspect not just yet. T

3 comments:

  1. He already posted about this:

    http://multiple-sclerosis-research.blogspot.com/2014/07/no-link-with-vitamin-d-levels-at-birth.html?m=1

    Are you sure MS isn't contagious because you are exhibiting problems with cognition?

    ReplyDelete
  2. This is a repeat post. Prof G posted on this a few days ago.

    ReplyDelete
    Replies
    1. must have been written before ProfG posted his comment

      Delete

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