Tecifidera is a topic being talked about in AVTRIMS 2013. A number of presentations has been talking about Nrf2
as a mechanism and it was even suggested that this could be a bad thing. So I draw your attention to this EAE study which suggest that Tecfideramay work via hydroxycarboxylic acid receptor 2 the niacin receptor
and stimulation of this can lead to flushing which is a side effect of tecfidera. in a mouse that lacks this receptor dimethyl fumarate stops working.