Friday, 3 October 2014

Another mechanism for Glaterimer Acetate now its B cells

Ireland SJ, Guzman AA, O'Brien DE, Hughes S, Greenberg B, Flores A, Graves D, Remington G, Frohman EM, Davis LS, Monson NL. The Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells From Patients With Relapsing-Remitting Multiple Sclerosis. JAMA Neurol. 2014 Sep doi: 10.1001/jamaneurol.2014.1472. [Epub ahead of print]

IMPORTANCE: This study describes what is, to our knowledge, the previously unknown effect of glatiramer acetate therapy on B cells in patients with relapsing-remitting multiple sclerosis (MS).
OBJECTIVE: To determine whether glatiramer acetate therapy normalizes dysregulated B-cell proliferation and cytokine production in patients with MS.
DESIGN, SETTING, AND PARTICIPANTS: Twenty-two patients with MS who were receiving glatiramer acetate therapy and 22 treatment-naive patients with MS were recruited at The University of Texas Southwestern Medical Center MS clinic. Cell samples from healthy donors were obtained from HemaCare (Van Nuys, California) or Carter Blood Bank (Dallas, Texas). Treatment-naive patients with MS had not received any disease-modifying therapies for at least 3 months before the study.
EXPOSURES: Glatiramer acetate therapy for at least 3 months at the time of the study.
MAIN OUTCOMES AND MEASURES: B-cell phenotype and proliferation and immunoglobulin and cytokine secretion.
RESULTS: A restoration of interleukin 10 production by peripheral B cells was observed in patients undergoing glatiramer acetate therapy as well as a significant reduction of interleukin 6 production in a subset of patients who received therapy for less than 32 months. Furthermore, proliferation in response to high-dose CD40L was altered and immunoglobulin production was elevated in in vitro-activated B cells obtained from patients who received glatiramer acetate.
CONCLUSIONS AND RELEVANCE: Glatiramer acetate therapy remodels the composition of the B-cell compartment and influences cytokine secretion and immunoglobulin production. These data suggest that glatiramer acetate therapy affects several aspects of dysregulated B-cell function in MS that may contribute to the therapeutic mechanisms of glatiramer acetate.

The saga of mechanisms of action of glaterimer acetate continues, here I am thinking its Treg, CD8 regulatory cells or Th2 etc etc and now the effect of Copaxone is affecting the B cell compartment. Is this activity the action of T regs or new function? 

What next a cure for ebola..only joking (please see yesterdays post by Arie for details)

ProfG will be happy he thinks its all B cells. 

Forty years after copaxone was described and patent life is now expired, we still don't really know how it is working.

4 comments:

  1. Are all these mechanisms of action really reall? I think any kind of research is tough, but this drug, Copaxone, this is not an antibody or intelligently designed molecule to block a specific receptor or such. I thought these were just short peptides, slightly resembling myelin? Where is all this research coming from?

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  2. My thoughts exactly. As I've said before, I'm surprised it hasn't been found to be the cure for Ebola.

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  3. Re "we still don't really know how it is working": But isn't that true for all the DMTs including the interferons
    and even the more effective treatments (natalizumab/alemtuzumab/... : does the effectiveness come from stop T-cells? or blocking B-cells?)

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  4. ...the market for Ebola is too small, it may however work against stupidity (largest market ever), it may significantly boost longevity, and most importantly will guarantee the buyer his spot in heaven (just helping to create new concepts for research directions)

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