Tuesday, 21 October 2014

The paralysed man walks again

7 comments:

  1. Do MS patients with spinal lesions exhibit similar glial scarring as found in traumatic SCI? In this study the glial scar tissue was removed before introduction of bulbar olfactory cells - I wonder if the same would apply to MS lesions?

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    1. MS lesions get scarring and the amount of scarring in spinal cord injury depends on the level of injury. In MS there may be scarring dotted throughout the brain and spinal cord and this would be difficult to remove surgically without consequence

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    2. Why not just concentrate on the spinal lesions?. Hopefully the neuro pathways would sort themselves out using plasticity.

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  2. This is a great story. I'm really hoping that some of the remyelination trials deliver some improvement. Even an improvement of 1 EDSS point to an MS patient would be brilliant. Keep up the good work.

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  3. Interesting, these OECs were used to bridge the gap in the transacted cord. I guess this would not be considered stem cell therapy since these are not precursor cells, a novel approach

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    1. OEC are considered a type of "stem cell" in terms of stem cell therapy but you are right they are radial glia and perform a variety of functions. OEG are also known to support and guide olfactory axons, grow through glial scars, and secrete many neurotrophic factors.

      If you were able to watch TV in UK yesterday to see the operation you could see that they had about a million cells and injected then at multiple sites, they also transplanted a peripheral nerve to fill the gap and make a pathway through which the OEC could stimulate the regrowth of nerves. Nerve bridge the gap.

      It is interesting to see the science reaction....some think it is amazing and then there are those that are muttering about the significance of the work. They have had their pipe dream exploded realising that they will not be the first to do this.....Thats science life I am afraid and they just need to get over their ego and assimilate what has happened and improve on it. :-)

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    2. The programme was exciting news. However, even if it was suitable for MS, unless the cause is found the disease will always be hanging around to do more damage. You are correct Mousedoctor the doubters are upset they weren't the first. This science will be free and another gift to the World. No doubt it will take years to develop further, but who thought Tim Berners-Lee's invention would allow me to write this post 20 years ago.

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