Wednesday, 17 December 2014

Advent Calendar 17

So we are telling you the story of drug development. We have the finance in place and the test tube data indicating the safety of the drug and now we have to go to animals to work out if the drug is safe.

You have to do formal toxicity studies in animals and start off in a small mammal species usually mice and rats and occasionally bunnies.
These studies are done by specialist CRO and their use is highly emotive. They and their staff are targeted by anti-vivisectionists, who in the UK can be very militant. 

In the 1970's and 1980's there used the occasional letter bomb sent by these militants to scientists working with animals. I can remember a worker who used to work with non-human primates who had their car checked over every day for bombs before they go in the car. Those working at the animal breeders or CRO were targeted. People working with guinea pigs were targeted (Save the Newchurch Guinea pigs). Few people working on MS models work with this species, despite it being one of the best demyelinating models. 

These actions meant that UK scientists have become a bit silent when talking about animal research, unlike in the US where animal experiments are in the media, every day. 

The UK government started to target these militant groups in the noughties and want scientists to be a bit more open about what they do but there is still a culture of silence....it is not about being secretive because people are doing underhand stuff...they are not...but there are still some nutters out there and why bring attention to yourself or your family.

You generally test your drug for a month as a start off but depending on how long you want to treat humans will depend on how long the animal tests need to be tested. We were pleased to say that not one single rodent died because of toxicity of our drug.

CoI. We are developing the drug for the treatment of MS symptoms

Based on some "spammed" comments from I wonder who or what....it seems someone doesn't like the Mice and has asked for "a picture of an overweight Yorkshireman with silly pony tail and earring and AC/DC shirt"...Can't think why.....I prefer the mice don't you?
:-)

16 comments:

  1. What type of MS will your drug help with, if it works?
    Thanks

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    Replies
    1. It's to treat symptoms (spasticity) arising from progressive MS.

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    2. When will your spasticity drugs come to market?

      Of the current anti-spastic drugs out there, which one do you rate the best?

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    3. Thanks, MD... geat cartoon - should you be offended?

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    4. Yes I think I was meant to offended...it was probably BE that sent it.

      When will it come to market....I don't know. There is testing still to do and it depends who develops it assuming it works well enough.. How long? If a proper pharma company was doing it, it should have come to market by now.

      Which current drug do I think is best.......the one that works for you with the least side effects

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    5. How many effective drugs are there for spasticity in SPMS?

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    6. I can think of Baclofen, Gabapentin and Tizanidine and Sativex off the top of my head. All come with side-effects (drowsiness, cognitive fog etc) which can limit their usefulness, though perhaps less for Sativex if you believe the hype, which is why we're trying to develop one without such negative side-effects.

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    7. Thank you Mousedoctor2, read the Sativex side effects I'll wait for you develop it.

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  2. Uncanny resemblace if you swap T shirt for Iron Maiden ;-)

    Huhhuhuhuhuhuhuhuhuhuhuhuhuhuhuhuhuhuhuu..............................

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  3. Yep, I prefer the mice pics ... but please, please don't mention bunnies, I was traumatised by Watership Down as a chlid. I'm writing this with a Syrian hamster sitting next to me. I'm not sure she'd (her name is Yuki Mocha) approve of your work;).

    ReplyDelete
    Replies
    1. Nope, born and bred in the UK, as far as I know there are now no Syrian hamsters in the wild. It's not my hamster but my brother's and lives in a hamster palace, seriously very very large cage with a penthouse on top. But occasionally decides to sit with people (thankfully doesn't try to escape) but is a bit anti-social.

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    2. Yes bunnies would traumatise me too.....I think your "Nasty Coffee" would approve that we also don't go near Hamsters

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    3. Anti-social...maybe because you don't speak her language:-)

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    4. Hey, not nasty coffee but happy (Japanese) coffee (her colouring is like mocha coffee). Yep, I don't speak her language (I prefer a bigger non-human animals like dogs, although recently I've become quite attached to a disabled goose that I feed ) but we have reached an understanding that involves giving her lots of sunflower seeds.

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    5. Thanks for this and make sure you dont create frois gras:-)

      Whilst I know Yucky I was not aware that Yuki can be: snow, tender princess (sure), courage, hapiness, valuable reason...I learn things every day.

      However I apologise in advance for the next stage of drug development for tomorrow....you won't like it.

      Delete

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