Thursday, 15 January 2015

UTI on Ampyra is not different

Kantor D, Chancellor MB, Snell CW, Henney Iii HR, Rabinowicz AL. Assessment of confirmed urinary tract infection in patients treated with dalfampridine formultiple sclerosis. Postgrad Med. 2015 :1-5. [Epub ahead of print]

Abstract Urinary tract infections (UTIs) were reported frequently with dalfampridine extended-release (dalfampridine-ER) 10 mg relative to placebo in previous multiple sclerosis (MS) studies. The objective of this study was to determine whether dalfampridine-ER is associated with increased incidence of confirmed UTIs in MS patients. This post hoc analysis used UTI data from a study comparing the 4-week safety and efficacy of 5 mg (n = 144) and 10 mg (n = 142) twice-daily dalfampridine-ER versus placebo (n = 143). To confirm UTIs, three clinical assessments were used: standard urinalysis (leukocytes > 5/high-power field); urine culture (≥ 100,000 and ≥ 10,000 colony-forming units [CFUs]/mL) for those who reported UTIs as adverse events (AEs) or had positive urinalysis; and UTI symptomatology. The proportion of patients who reported UTIs as AEs in the placebo and dalfampridine-ER 5 mg and 10 mg groups were 5.6%, 6.3%, and 9.9%, respectively. In comparison, those with laboratory-confirmed UTIs were lower: ≥ 100,000 CFUs/mL: 4.2%, 2.8%, and 2.8%; and ≥ 10,000 CFUs/mL: 4.2%, 3.5%, and 4.9%, respectively (no significant statistical difference across treatments). The proportion of patients with confirmed UTI was similar between dalfampridine-ER and placebo, thus suggesting that the treatment does not increase the risk of UTIs.

You can read the conclusions but this post reposts that there are no increases in urinary tract infections after Fampridine

4 comments:

  1. Fampyra sounds like a drug to treat vampires. Couldn't they come up with a better name?

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  2. Oops I bet biogen have been pinving emails to profG. Fire the type setter. The real name is Ampyra not Fampyra I will change.
    However it will suck the money out of your wallet so Vampire analogy is very good

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    Replies
    1. Actually Fampyra is the name it is branded under in Europe and Ampyra is used in the U.S. This makes sense because vampires originated from eastern Europe.

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    2. Thanks I was aware of US and Europe had different name I didnt have time to check what it was I know it as fampridine and dalfampridine

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