Friday, 27 February 2015

Shift work gives you MS

Hedström A, Åkerstedt T, Olsson T, Alfredsson L.Shift work influences multiple sclerosis risk. Mult Scler. 2015 Feb. pii: 1352458514563592. [Epub ahead of print]

BACKGROUND:An association between working shift at a young age and subsequent risk for multiple sclerosis (MS) has been observed.
OBJECTIVE:To investigate whether this finding could be replicated, and to further explore the influence of age at first exposure to shift work.
METHODS:Using a Swedish population-based, case-control study (2337 cases and 4904 controls), the incidence of MS among subjects whom had worked shifts was compared with that of those whom had not, by calculating odds ratios (ORs) with 95% confidence intervals (CIs) by means of logistic regression.
RESULTS:The OR of developing MS was 1.5 (95% CI 1.2-1.8) among those whom started working shifts before age 20, whereas a less pronounced association was observed among those whom started working shifts at age 20 or later (OR 1.2; 95% CI 1.1-1.4). The effect of shift work was more pronounced among subjects whom had been exposed at a young age, regardless of the duration between the start of shift work and disease onset.
CONCLUSION:Some aspects of adolescence seem to be of great importance, regarding the impact of shift work on MS risk. Circadian disruption and sleep deprivation may contribute towards explaining the association; however, the exact mechanisms behind our observations remain to be elucidated.


So we have smoking, sunlight exposure, toxic chemicals and this one suggests shift work so this study suggests that if you did shift work then you are more likely to get MS 1.2 times more likely. This is  small risk and many if not most of you will never done shift work. 

However I suggest we do not avoid all shift work but sign up to the community of Shift.ms (if it is the place or you)




3 comments:

  1. Yes I have done night shift work unfortunately. There was something in the news today about how smartphones hurt sleep. Tablets and smartphones in bed or near bedtime can change sleep systems. The blue light can surpress melatonin.

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  2. May be this has something to do with pineal gland calcification in MSers?
    A study (1991) by Sandyk R, and Awerbuch G.I published in the International Journal of Neuroscience, it was shown that Pineal Calcification was found in 100 % of MS patients.
    Has this been discussed before Team G, that MSers may have pineal gland abnormalities?
    The pineal gland is responsbile for the production of melatonin.. Melatonin increases immune memory. If the pineal gland is impared then this effects the pituitary gland.
    I'm no doctor, I just have MS.

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  3. I've never done shift work (i'm a boring accountant), but got MS. I never smoked and got plenty of sunshine. I did get a bad case of mono as a teenager. I think ebv is the biggest risk factor. My two friends who do shiftwork as a nurse and a policeman. It would be interesting to know the level of MS amongst nurses and police compared with office workers. Perhaps the explanation is simpler - shift workers ger less good quality sleep which affects there ability to fight off viruses etc. they are then more prone to ebv becoming reactivated and the inflammatory cascade which leads to MS kicks off........

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