Saturday, 16 May 2015

Adolescence is the time for vitamin D

Cortese M, Riise T, Bjørnevik K, Holmøy T, Kampman MT, Magalhaes S, Pugliatti M, Wolfson C, Myhr KM. Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study. Mult Scler. 2015 May. pii: 1352458515578770. [Epub ahead of print]

BACKGROUND: Low vitamin D levels have been associated with an increased risk of multiple sclerosis (MS), although it remains unknown whether this relationship varies by age.
OBJECTIVE: The objective of this paper is to investigate the association between vitamin D3 supplementation through cod liver oil at different postnatal ages and MS risk.
METHODS: In the Norwegian component of the multinational case-control study Environmental Factors In Multiple Sclerosis (EnvIMS), a total of 953 MS patients with maximum disease duration of 10 years and 1717 controls reported their cod liver oil use from childhood to adulthood.
RESULTS:Self-reported supplement use at ages 13-18 was associated with a reduced risk of MS (OR 0.67, 95% CI 0.52-0.86), whereas supplementation during childhood was not found to alter MS risk (OR 1.01, 95% CI 0.81-1.26), each compared to non-use during the respective period. An inverse association was found between MS risk and the dose of cod liver oil during adolescence, suggesting a dose-response relationship (p trend = 0.001) with the strongest effect for an estimated vitamin D3 intake of 600-800 IU/d (OR 0.46, 95% CI 0.31-0.70).
CONCLUSIONS: These findings not only support the hypothesis relating to low vitamin D as a risk factor for MS, but further point to adolescence as an important susceptibility period for adult-onset MS
We have been supporting the use of Vitamin D supplementation in MSers, because it helps to maintain bone health. There are loads of trials on the go but will we get an earth shattering result. ProfG hopes so, but when do you need to supplement. Neutriceuticals don't have many side effects unless you scoff loads so are they going to have a big impact...we shall see.

What this study does is that it looks at cod liver oil supplementation and the risk of subsequently developing MS. The data suggests that risk is not reduced if you just supplement during childhood but if you supplement during adolescence then the risk of MS was halved. The more cod liver oil, hence vitamin D you had the lower the risk of MS. However the supplements were lower than suggested currently doses.

This fits with the migration studies which looks at risk if you migrate before or after the age of 15 from low to high MS risk areas and suggests you encounter the MS risk problem in adolescence. Is this EBV, if so has the Charcot project 1 missed the window? 


6 comments:

  1. BTW: Vitamin D is inhibiting IL-6 production.

    http://www.ncbi.nlm.nih.gov/pubmed/16618780
    http://www.ncbi.nlm.nih.gov/pubmed/22301548
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219316/

    ReplyDelete
  2. This blog has completely evaded answering on news reports linking vitamin D to increased risk of stroke (http://www.express.co.uk/life-style/health/563890/Dangers-oVitamin-D-Risk-stroke-heart-attack-increase).

    You're very selective on the good and bad side of science reporting if it is detrimental to your agenda.

    ReplyDelete
    Replies
    1. WE RELY ON YOU TO FIND THINGS AS WE DO NOT SEE EVERY PAPER AND AS I AM NOT A VITAMIN D OR STROKE RESEARCHER I AM NOT GOING TO SEE EVERY THING AND I DON'T READ THE EXPRESS SORRY. PROFG IS INTERESTED IN VITAMIND AND HAS BEEN ON SABBATICAL FOR 6 MONTHS. BUT HERE YOU GO.

      http://www.ncbi.nlm.nih.gov/pubmed/25710567
      A reverse J-shaped association between serum 25-hydroxyvitamin D and cardiovascular disease mortality - the CopD-study.
      Durup D, Jørgensen HL, Christensen J, Tjønneland A, Olsen A, Halkjær J, Lind B, Heegaard AM, Schwarz P.
      J Clin Endocrinol Metab. 2015 :jc20144551. [Epub ahead of print]

      CONTEXT: Cardiovascular disease is the major cause of death in the Western World, but the association between 25-hydroxyvitamin D levels and the risk of cardiovascular disease mortality remains unclear OBJECTIVE: To determine the association between cardiovascular, stroke and acute myocardial infarct mortality and serum levels of 25(OH)D
      DESIGN: Observational cohort study, the CopD Study, data from a single laboratory center in Copenhagen, Denmark. Follow-up 2004 to 2011
      SETTING: Serum 25(OH)D was analyzed from 247,574 subjects from the Copenhagen general practice sector PARTICIPANTS: Examination of the association 25-hydroxyvitamin D levels and mortality from cardiovascular disease, stroke and acute myocardial infarct among 161,428 women and 86,146 men
      RESULTS:
      Out of 247,574 a total of 16.645 subjects died in the ensuing 0-7 years. 5,454 died from cardiovascular disease including 1,574 from stroke and 702 acute myocardial infarct. 25-hydroxyvitamin D level of 70 nmol/L was associated with the lowest cardiovascular disease mortality risk. [SO PEOPLE WHO ARE VITAMIN D SUFFICIENT HAVE THE THE LOWEST RISK OF HEART ATTACK) Compared to that level the hazard ratio for cardiovascular disease mortality was 2.0(95% CI 1.8-2.1) at the lower extreme (∼12.5 nmol/L) with higher risk for men 2.5(95% CI 2.2-2.9), than for women 1.7(95% CI 1.5-1.9). [SO PEOPLE WHO ARE VITAMIN D DEFICIENT HAVE TWICE THE RISK OF HEART ATTACK. At the higher extreme (∼125 nmol/L), the hazard ratio of cardiovascular disease mortality was 1.3(95% CI 1.2-1.4), with similar risk among men and women [IF YOU HAVE HIGHER THAN NORMAL LEVEL YOUR RISK OF HEART ATTACK IS SLIGHTLYINCREASED]. Results were similar for stroke and acute myocardial subgroups [RESULTS WERE SIMILAR TO STROKE..THEREFORE THE RISK OF BEING VITAMIN D DEFICIENT IS OUTWEIGHTED BY HAVING TOO MUCH)
      CONCLUSIONS: In this large observational study low and high levels of 25-hydroxyvitamin D were associated with cardiovascular disease, stroke and acute myocardial mortality in a non-linear, reverse J-shaped manner [???? I HAVE NO TIME TO EPLAIN THIS], with highest risk at lower levels. Whether this was a causal or associational finding cannot be determined from our data [MORE STUDIES ARE NEEDED AS IT IS NOT CLEAR IF THERE IS CAUSE AND EFFECT]. There is a need for randomized clinical trials which include information on the effects of 25-hydroxyvitamin D levels above 100 nmol/L. [TRIALS ARE ON GOING AND IT WILL SHOW IF THIS IS REAL CONCERN]

      PROF G MAY COMMENT

      Delete
    2. Hey, thanks MouseDoctor. That was pretty helpful.

      Delete
  3. Diagnosed 3 yrs ago ... Female age 46yrs... RRMS ... Prob had it for years.... Should I be giving my daughters age 16 and 18 Vit D3?? If so how much? I take 5000 iu daily. Thanks :-)

    ReplyDelete
    Replies
    1. THIS IS RECOMMENDED DOSE THIS IS ON BLOG PLEASE SEARCH

      Delete

Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.