Sunday, 12 July 2015

How big is your Brain..depends on the scanner

Chu R, Tauhid S, Glanz BI, Healy BC, Kim G, Oommen VV, Khalid F, Neema M, Bakshi R.Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients withMultiple Sclerosis. J Neuroimaging. 2015. doi: 10.1111/jon.12271. [Epub ahead of print]
BACKGROUND:Whole brain atrophy is a putative outcome measure in monitoring relapsing-remitting multiple sclerosis (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. We evaluated brain parenchymal volumes (BPVs) from 1.5T versus 3T in MS and normal controls (NC).
METHODS: We studied MS [n = 26, age (mean, range) 43 (21-55), 22 (85%) RRMS, Expanded Disability Status Scale (EDSS) 1.98 (0-6.5), timed 25 foot walk (T25FW) 5.95 (3.2-33.0 seconds)] and NC [n = 9, age 45 (31-53)]. Subjects underwent 1.5T (Phillips) and 3T (GE) 3-dimensional T1-weighted scans to derive normalized BPV from an automated SIENAX pipeline. Neuropsychological testing was according to consensus panel recommendations.
RESULTS: BPV-1.5T was higher than BPV-3T [mean (95% CI) + 45.7 mL (+35.3, +56.1), P < .00001], most likely due to improved tissue-CSF contrast at 3T. BPV-3T showed a larger volume decrease and larger effect size in detecting brain atrophy in MS versus NC [-74.5 mL (-126.5, -22.5), P = .006, d = .92] when compared to BPV-1.5T [-51.3.1 mL (-99.8, -2.8), P = .04, d = .67]. Correlations between BPV-1.5T and EDSS (r = -.43, P = .027) and BPV-3T and EDSS (r = -.49, P = .011) and between BPV-1.5T and T25FW (r = -.46, P = .018) and BPV-3T and T25FW (r = -.56, P = .003) slightly favored 3T. BPV-cognition correlations were significant (P < .05) for 6 of 11 subscales to a similar degree at 1.5T (r range = .44-.58) and 3T (r range = .43-.53).
CONCLUSIONS:Field strength may impact whole brain volume measurements in patients with MS though the differences are not too divergent between 1.5T and 3T.




If you have your brain scanned with a 3 T machine it can appear smaller than having a scan in a 1.5T because 3T is a more powerful machine and the edges of a 1.5T scanner are more wooly. 

2 comments:

  1. "Smoking could play a direct role in the development of schizophrenia and needs to be investigated, researchers say."

    http://www.bbc.co.uk/news/health-33464480

    Why is it, then, that cigarettes continue to be sold when they're clinically sabotaging our brains?

    ReplyDelete
    Replies
    1. I noticed this too.
      I also read on another web page that the hit of a cigarette only lasts for 20 minutes or less. It's pointless poison.

      Delete

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