Friday, 28 August 2015

Improved walking with medical cannabis

Coghe G, Pau M, Corona F, Frau J, Lorefice L, Fenu G, Spinicci G, Mamusa E, Musu L, Massole S, Massa R, Marrosu MG, Cocco E.J 
Walking improvements with nabiximols in patients with multiple sclerosis. Neurol. 2015 Aug 5. [Epub ahead of print]

Recently, nabiximols was approved as a treatment in MS spasticity. Data leading to approval and clinical use of nabiximols, although widely recognised, are based on subjective scales. Movement analysis procedures would obtain more detailed data about the impact on mobility. The aim of the study was to quantitatively assess the functional modification of gait patterns induced by nabiximols in MS. We evaluated three-dimensional gait analysis (spatial-temporal and kinematic) variation by means of one-way ANOVA. Twenty patients were enrolled-9 male and 11 female-with mean EDSS of 5.3 (SD ± 0.81) and mean reduction of numerical rating scale during nabiximols treatment of 1.88. The spatial-temporal parameters of gait revealed an increased speed (+15 %, p < 0.001), cadence (+6 %, p < 0.001) and stride length (+10 %, p < 0.001) after treatment. Regarding the kinematics data, the Gait Profile Score after treatment was reduced by 10 % (p < 0.001): Significant changes involved the pelvic area, hip rotation and knee flexion-extension. We found that nabiximols is able to improve the speed, cadence and stride length. Furthermore, the dynamics of the proximal segment of the legs and the knee movement results after treatment are closer to the physiologic values.

You can read the conclusions if interested. If the drug helps spasticity you would hope that it improves mobility. 

3 comments:

  1. What a shame the stigma promoted by right wing press hampers access to cannabis derived drugs. imho.

    Regards as always

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  2. Someone I knew during my student days assured me that you don't have to smoke cannabis. It's fat soluble so you can bake it into cakes. If I'm not allowed to try the medical stuff, maybe I could grow a little tucked away behind my houseplants and try it in a ginger cake? Could be a magical recipe.

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