Sunday, 23 August 2015

Vitamin D and Th9 cells

Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells.Takami M, Fujimaki K, Nishimura MI, Iwashima M.
J Immunol. 2015. pii: 1500344. [Epub ahead of print]

The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation.
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CD4(+) T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Th9 cells might be involved in pathogen immunity and immune-mediated disease. (review click here). In this study they report that vitamin D suppresses BAFT (Basic leucine zipper transcription factor, ATF-like) and reduces the Aryl_hydrocarbon_receptor. Is this how vitaminD affects multiple sclerosis?


4 comments:

  1. When you increase vitamin d intake significantly the levels of 25(OH)D in the blood rise, but if anything the levels of 1,25(OH)D in the blood fall, but only slightly. Is there any evidence that 1,25(OH)D production can increase locally without affecting blood levels. If not how would this be working.

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  2. Why neurologist in UK not recommended intake high doses vitamin D for MSers?

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  3. I would also like to understand the mechanism behind the vitamin D, specifically D3, which is the way I take it every day 10.000 ui, prescribed by my neurologist ...

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  4. http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001866
    Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

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