Wednesday, 30 September 2015

Sex hormones and glucose

Triantafyllou N, Thoda P, Armeni E, Rizos D, Kaparos G, Augoulea A, Alexandrou A, Creatsa M, Tsivgoulis G, Artemiades A, Panoulis C, Lambrinoudaki I.Association of sex hormones and glucose metabolism with the severity of multiple sclerosis. Int J Neurosci. 2015:1-8. [Epub ahead of print]

Purpose/Aim of the study: We evaluated possible associations between the severity of multiple sclerosis (MS) and levels of sex hormones as well as biochemical parameters in a sample of ambulatory patients.
MATERIAL AND METHODS:This cross-sectional study recruited 133 adults (52 men, 66 premenopausal and 15 postmenopausal women), with relapsing-remitting MS. Fasting venous blood samples were drawn for biochemical and hormonal evaluation. These parameters were tested for possible associations with MS severity, assessed using the Expanded Disability Status Scale (EDSS)-scores.
RESULTS:Follicle-stimulating hormone correlated with mean EDSS scores (r = -0.369, p = 0.038) in the premenopausal subgroup. However, this association became non-significant in the age-adjusted multivariate analysis (p = 0.141; power = 67%, type α error 0.10). Free androgen exhibited a borderline negative effect on EDSS-scores in the subgroup of men (r = -0.367, p = 0.093), which was lost after adjusting for age and duration of disease (p = 0.192; statistical power = 93%, type α error 0.05). Levels of oestradiol tended to affect disability status of postmenopausal women (normal-mild vs. severe impairment: 23.33 ± 11.73pg/mL vs. 14.74 ± 6.30pg/mL, p = 0.095). Levels of sex hormones or indices of glycemic metabolism did not differ between patients presenting with EDSS scores higher or lower than the median value.
CONCLUSION:Sex hormones and indices of glucose metabolism exhibited only a middle effect on EDSS scoring, which was not independent from the presence of confounders like age and duration of MS. The present study highlights the need for additional research, in order to elucidate the role of sex hormones and insulin resistance in the course of MS.
This study looks at the influence of hormones on MS and again we have the dreaded r=-0.4 as being interesting. 

Some of you buy this,  I don't.  A correlation of r=0.4 or r=-0.4 tells us very little about the individual and so here the FSH hormone levels showed essentially nothing , The levels of osestrodiaol showed essentially nothing and the levels of testosterone showed essentially  nothing.  

P=0.05 gives a probability of one in twenty chance that the result obtained is a fluke. In science-land P>0.05 means there is no effect, do it again with a bigger group size or find something more interesting,  but in clinical-science-land it means almost interesting. Look at the graph above for what an r=0.4 looks like, can you see an interesting correlation?

2 comments:

  1. But there must be some component connected to MS and the increase in incidence in women ... and where the theory for EBV would fit it, this increase in cases among women?

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    Replies
    1. Increase in women....I guess its sex hormones and EBV doesnt have to be higher in women

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