Sunday, 11 October 2015

Vitamin D enhance suppressive cytokines but does it stop MS

Ashtari F, Toghianifar N, Zarkesh-Esfahani SH, Mansourian M. Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients with Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Neuroimmunomodulation. 2015 Sep 25. [Epub ahead of print]

BACKGROUND: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Vitamin D has been related to the prevention of MS and to modulating its course. Recent studies have shown the safety of high-dose vitamin D in MS.
OBJECTIVE:This study compared the effects of high-dose vitamin D on interleukin 10 (IL-10) levels in MS patients in a double-blind, randomized clinical trial.
METHODS:Ninety-four patients with relapsing remitting MS (RRMS) were randomized into a treatment and a placebo group. Both groups received conventional MS treatment. The intervention group received 50,000 IU of vitamin D every 5 days for 3 months. IL-10 was measured at baseline and after 3 months.
RESULTS:Serum levels of IL-10 were (median ± IQR): 12.58 ± 11.97 and 10.97 ± 9.97 pg/ml in the intervention and placebo groups, respectively, at baseline (p = 0.161); after 3 months, these levels were 13.76 ± 18.95 and 11.31 ± 19.63 pg/ml, respectively (p = 0.158). The IL-10 level increased significantly after receiving high-dose vitamin D for 3 months (β = 0.737, p = 0.015 and R2 = 0.91).
CONCLUSION:IL-10 levels increased significantly in RRMS patients after taking high-dose vitamin D3 for 3 months. High-dose vitamin D might be useful in promoting an anti-inflammatory state in RRMS patients.
I was hoping that ProfG was going to post on this one as VitaminD is his thang and he's a glass half-full person. 

So in this study if you take massive amounts of vitamin D your blood levels of interleukin-10 goes for 13pg/ml to 14pg/ml (Whoopee-Do).  Free cytokine in blood means to me the excess to what is needed following binding to the IL-10  receptors on cells. 

To many T cell immunologists, IL-10 is an immunosuppressive cytokine that mediates T regulatory function. However, if you are a B cell immunologist it makes B cells grow. So far IL-10 has not proved to be therapeutically useful.  

However, what does this mean will your MS go away? This is the question we need to ask.  Then we need to ask is when is vitamin D important in the development of MS.

Enjoy the Indian Summer we are supposed to get and remember a few minutes in the sun is going to give you more vitamin D than you get from food & supplements, but remember no more than 15minutes without sunscreen.

11 comments:

  1. 50,000Iu every 5 days is 10,000IU a day which is not massive. It is within the dose known not to cause toxicity. If you take the dose recommended for babies and scale by weight (volume) to an adult you get a dose close to this. Baby 2.5 kg 400IU a day : Adult 70kg 11200IU a day.

    At the moment, in the UK, the sun is not giving you any vitamin d no matter how long you spend out side. The UK is now in its vitamin d winter and the next time you make vitamin d from sun exposure will be next April. The chemical reaction that leads to the formation of vitamin d on the skin requires specific wavelengths of UVB NOT SUNLIGHT. When the sun is low in the sky the UVB is absorbed by the atmosphere.

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    1. According to this Shift MS video on Vitamin D with consultant neurologist Belinda Weller in the UK if you live north of Birmingham you will not make Vit D October to April when the sun is out.
      https://www.youtube.com/watch?v=X4uRtdk1-pQ&list=PLVUOB ZqvZOFB77BtPV4VAMehp7WDaKcp

      I live south of Birmingham so I may get some vit D from the sun in October.

      Delete
  2. The trial participants took 10,000iu a day for only 3 months. This is quite a short trial.

    The Vitamin D Council state the following:

    "Very high levels of 25(OH)D can develop if you:

    Take more than 10,000 IU/day (but not equal to) everyday for 3 months or more. However, vitamin D toxicity is more likely to develop if you take 40,000 IU/day everyday for 3 months or more.
    Take more than 300,000 IU in a 24 hour period.

    If you have taken this much vitamin D, seek medical attention. Your health providers will get your calcium and 25(OH)D levels tested."

    https://www.vitamindcouncil.org/about-vitamin-d/am-i-getting-too-much-vitamin-d/

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  3. I understand that a little bit amount VitD such as 10.000 ui per day is very useful in MS. Why all neuros in UK don't recommend this?

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  4. "Enjoy the Indian Summer we are supposed to get"
    MD, it's October! A winter very possibly influenced by El Niño is on the way!

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  5. From what I read 10,000iu a day seems ok to take for up to six months. Beyond six months there may be toxicity signs, depends on the person.

    Obese people may need more vit D.

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    1. If you have not reached toxicity in 6 months on the dose you are on you never will. The consumption of vitamin d increases with supply, and vitamin d has a half life so your 25(OH)D levels off. The only known toxic effect of vitamin d is disruption of the blood calcium levels.

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    2. Re "If you have not reached toxicity in 6 months on the dose you are on you never will".

      I'm not sure I agree with this view, where are you getting your information from?

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    3. For vitamin d to become toxic the blood level of 25(OH)D has to exceed a certain level. So what you are asking is does the blood level of 25(OH)D keeping increasing for a fixed input and the answer is no. See Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety Reinhold Vieth Am J Clin Nutr May 1999 vol. 69 no. 5 842-856

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  6. You pseudo-scientists have not yet commented on the large errors!!!

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    Replies
    1. They are not errors, it is variability (spread) about the median.

      Delete

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