Friday, 16 October 2015

Young, fat and pastey.....increase your risk of MS.

Laursen JH, Søndergaard HB, Sørensen PS, Sellebjerg F, Oturai AB. Association between age at onset of multiple sclerosis and vitamin D level-related factors. Neurology. 2015 Oct 7. pii: 10.1212/WNL.0000000000002075. [Epub ahead of print]

OBJECTIVE:To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.
METHODS:This cross-sectional study included 1,161 Danish patients with MS; lifestyle questionnaires and blood samples for genotyping were collected from all participants from 2009 to 2012. Information on age at onset was obtained from the Danish MS Treatment Registry. Written informed consent was obtained from all study participants, and the study was approved by the local ethics committee.
RESULTS:Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis. No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors.
CONCLUSION:We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.
Yet more association studies in the Danish registries into risk factors for MS. What else would be associated with this risk, many things I suspect

5 comments:

  1. I've never seen a young fat person with MS in my life. In fact quite the opposite. Getting depressed if this is all they can come up with.

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    1. Well it certainly describes me in many of my younger years pre-diagnosis. Hopefully avoiding those risk factors moving forwards will help!

      Well apart from the age thing - file that under 'out of my control'

      Delete
  2. I think it's not just MS but diabetes etc. Fat causes low-grade inflammation in your tissue and if you don't go outside you won't get Vit D to mitigiate the fat effect. Not just MS typical but wide range of illnesses.

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    1. Fat also lowers vitamin d levels in the blood for a given intake. Whether this is simple dilution or something more complex I don't think we know.

      This is just confirming known risk factors not adding new ones. Get your children out in the sun, keep their vitamin d levels up and try and keep their weight down. This appears to reduce the risk of MS starting but it says nothing about what happens afterwards.

      In the UK the RDA for a new born baby is now higher than that for an adult and this is for something measured in mass per unit volume.

      Delete

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