Ashtari F, Emami P, Akbari M.Association between retinal nerve fiber layer thickness and magnetic resonance imaging findings and intelligence in patients with multiple sclerosis.
Adv Biomed Res. 2015 Oct 7;4:223. doi: 10.4103/2277-9175.166646. eCollection 2015.
BACKGROUND:Multiple Sclerosis (MS) is a neurological disease in which demyelination and axonal loss leads to progressive disability. Cognition impairment is among the most common complication. Studying axonal loss in the retina is a new marker for MS. The main goal of our study is to search for correlations between magnetic resonance imaging (MRI) findings and the retinal nerve fiber layer (RNFL) thickness at the macula and head of the optic nerve and Wechsler Adult Intelligence Scale-Revised (WAIS-R) Scores that assess multiple domains of intelligence, and to explore the relationship between changes in the RNFL thickness with intellectual and cognitive dysfunction.
MATERIALS AND METHODS:A prospective cross-sectional study was conducted at the University Hospital of Kashani, Isfahan, Iran, from September to December 2013. All patients were assessed with a full-scale intelligence quotient (IQ) on the WAIS-R. An optical coherence tomography study and brain MRI were performed in the same week for all the patients. Statistical analysis was conducted by using a bivariate correlation, by utilizing SPSS 20.0. A P value ≤ 0.05 was the threshold of statistical significance.
RESULTS:Examination of a 100 patients showed a significant correlation between the average RNFL thickness of the macula and the verbal IQ (P value = 0.01) and full IQ (P value = 0.01). There was a significant correlation between brain atrophy and verbal IQ.
CONCLUSION:The RNFL loss was correlated with verbal IQ and full IQ.
We have been here before, does problems in the eye correlate with changes in the brain, yes the more brain lesions the greater chance you have eye problems is there an absolute correlation NO, if you have eye problems it does not mean you have brain problems and if you have brain problems it does not mean you will have eye problems...How many more papers on this subject matter? Loads I suspect