Coarelli et al. Characterization of Epstein–Barr virus genotypes in multiple sclerosis through next generation sequencing approaches. L Neuroimmunol 2014;08:209
Notwithstanding the highly converging evidence, the identification of the mechanisms responsible for the multiple sclerosis (MS)–Epstein–Barr virus (EBV) association remains difficult to clarify. The possibility that only a particular viral genotype associates with the disease is plausible and has been investigated by other groups, with conflicting results. We sequenced the most polymorphic region of the Epstein–Barr nuclear antigen 2 (EBNA2) in blood samples of MS patients and healthy donors (HD) and found an association between EBNA2 genetic variants and MS and a higher than expected breadth of new variants.
CoI: Team G will be recipients of a grant from Crowdacure to perform this research