They stain for myelin and you see myelin loss (look in B)
In the model you feed cuprizone. Myelin is lost. Stop feeding and there is remyelination. Give a drug remyelination occurs quicker.
This is post-inflammatory repair and so the translational aspect is to give after a relapse and then there should be better recovery. However, what you want to see is remyelination of chronic demyelinated, gliotic lesions?
So my mind this has never been attempted in animals, or if it has it has never been reported. Yet we are waiting for the read-out of the anti-LINGO trial in progressive MS.
So if it success then it is all down to the pre-clinical studies, but if it fails don't blame the animals. The anti-LINGO trial is delivering a drug where 99.9% is wasted because it never reaches the target using endpoints designed for relapsing remitting trials and MRI surrogates that abit loose. If remyelination occurs in animals it is complete in about 3 weeks, yet the trials are for 2 years. How much improvement are we going to see...Just keeping it real....but let's hope for a fantasical result.