Tuesday, 19 April 2016

Tregs to the rescue


Eliseeva DD, Lifshits GV, Lokhonina AV, Zhdanov DD, Zavalishin IA, Bykovskaya SN. The treatment by expanded ex vivo autologous regulatory T-cells CD4+CD25+FoxP3+CD127low restores the balance of immune system in patients with remitting-relapsing multiple sclerosis]. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(2. Vyp. 2. Rassejannyyj skleroz):54-62. Russian.

AIM:To assess clinical efficacy and safety of the autologous (own) regulatory T-cells (Tregs)CD4+CD25+Foxp3+CD127low isolated from the blood of patients with remitting-relapsing multiple sclerosis. Patients with autoimmune diseases have the decreased number of peripheral Tregs (pTreg) and impaired suppressive ability. In order to restore levels of pTreg, it is possible to isolate precursor cells, enter expanded ex vivo autologous Treg cells and introduce an expanded amount of autologous cells as Treg vaccine.
MATERIAL AND METHODS:A method of ex vivo Tregs expansion by 30-40 times within 5-7 days has been developed. Expanded ex vivo Tregs are more than 90% CD4+CD25+Foxp3+CD127low and have high suppressor activity. Fourteen patients with remitting-relapsing multiple sclerosis were included in pilot studies.Ex vivoTregs were introduced subcutaneously in dosefrom 2.8 to 4.5 108 cell per injection. The duration of follow-up was 1 year.
RESULTS AND CONCLUSION:The numbers of pTregs in the blood of these patients elevated by 1.5-2 times. No adverse-effects, a decrease of relapses and stabilization of disability index were observed. It has been suggested that ex vivo expanded Tregs can compensate the impaired function of pTregs and can be used for adoptive immunotherapyof multiple sclerosis.

I can't read the paper but look at the title it states that transfer of Treg cells inhibits relapsing MS. Is human MS becoming EAE? Will this pan out? Therefore it is interesting that daclizumab which depletes T regs makes MS better. Whats going on?

6 comments:

  1. Mouse,

    I don't take much confidence when one of the authors is called Lifshits. I know you want EAE to be seen as MS, but it's not. When will this T cell, B cell ping pong ever end?

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    1. The fact it's only been published in a Rusian journal, when if the results are correct you'd have thought the likes of Nature/Science etc would be biting their hands off to publish does cast a certain amount of dubiety as to the veracity of this.
      If I'm being unfair to the authors then I apologise in advance.

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    2. Those guys (well at least one of them I know for certain) do commercial HSCT and other stem cell something in Russia, so why do they bother with publications in Nature? They need advertisement in russian journals, hehe

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    3. I'm starting to get a whiff of three week old mackerel for some strange reason. ;-)

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  2. Intriguing naive and foxy bits.

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    Replies
    1. Fnarr fnarr.
      http://viz.co.uk/category/cartoons/strip-cartoons/finbarr-saunders/

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