Water to the Rescue

Zhao M, Liu MD, Pu YY, Wang D, Xie Y, Xue GC, Jiang Y, Yang QQ, Sun XJ, Cao L. Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol. 2016;294:6-13.

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, anti-allergy, and anti-cancer effects. In the present study, we explored the prophylactic and therapeutic effects of hydrogen-rich water (HRW) on the progress of experimental autoimmune encephalomyelitis (EAE), the animal model for MS. We found that prophylactic administration of both 0.36mM and 0.89mM HRW was able to delay EAE onset and reduce maximum clinical scores. Moreover, 0.89mM HRW also reduced disease severity, CNS infiltration, and demyelination when administered after the onset of disease. Furthermore, HRW treatment prevented infiltration of CD4+ T lymphocytes into the CNS and inhibited Th17 cell development without affecting Th1 cell populations. Because HRW is non-toxic, inexpensive, easily administered, and can readily cross the blood-brain barrier, our experiments suggest that HRW may have great potential in the treatment of MS.

We are critisized for suggesting that pharma can and do produce drugs to treat MS that work (for some people with MS). Here is a non-pharma approach in EAE. Yep water. In this study you have hydrogen rich water, which can be made by placing a metallic magnesium stick into drinking water. However, in this case it 
was bought.

Is this going to replace DMT? 

So before you rush off of get some.

Remember in EAE  a  good DMT can eliminate disease not amelirorate it. 

Part II What was found?

Group        Incidence   Time of onset   Maximum score
Control       14 of 15     11.1 (± 0.9)        3.28 (± 0.5)   
(0.36 mM)   12 of 15     12.1 (± 0.4)⁎⁎           1.94 (± 0.16)⁎⁎ 
(0.89 mM)  12 of 15     13.7 (± 0.6)⁎⁎,           1.75 (± 0.27)⁎⁎,

In the same paradigm it would be 0/15 if you gave the animals fingolimod.

However, it was administered at 20ml/kg twice a day a so that is 0.5ml in a 25g mouse at twice a day, so that is 1ml a day. 

The current limit in the UK is 5ml/kg, so this is 4 times the limit and this result is probably a consequence of stress, as mice learn what is coming and twice a day can be stressful and the volume is so big that it will (osmotically=water balance) stress the animal meaning that animals will not get disease.

Put mice next to a building site and the incidence of EAE down, if you live next to a building site, does MS go away? 

So more good stuff from the Far East :-(, where it seems pharma are relocating their pre-clinical animal studies to.

It says "All animal experiments were performed in adherence with the National Institutes of Health Guidelines on the Use of Laboratory Animals and approved by the Second Military Medical University Committee on Animal Care". 

Did the first committee get canned for actually supporting the ethical use of animals :-(. 

Yes, I will get criticized for highlighting such issues. 
Pop Science or Plop science?:-(

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