Thursday, 12 May 2016

You are what you eat. Diet and Disease

Libbey JE, Doty DJ, Sim JT, Cusick MF, Round JL, Fujinami RS. The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. Nutrition. 2016 Jan 21. pii: S0899-9007(16)00039-3. 

OBJECTIVE:Many things can impact the reproducibility of results from laboratory to laboratory. For example, food from various sources can vary markedly in composition. We examined the effects of two different food sources, the Teklad Global Soy Protein-Free Extruded Rodent Diet (irradiated diet) and the Teklad Sterilizable Rodent Diet (autoclaved diet), on central nervous system disease.
METHODS: Three preclinical models for human disease: Two different experimental autoimmune encephalomyelitis models (multiple sclerosis) and the Theiler's murine encephalomyelitis virus-induced seizure model (epilepsy), were examined for the effects of two different food sources on disease.
RESULTS: We found that mice fed the irradiated diet had more severe clinical disease and enhanced seizures compared with animals provided the autoclaved diet in both experimental autoimmune encephalomyelitis models examined and in the Theiler's murine encephalomyelitis virus-induced seizure model, respectively.
CONCLUSIONS:Therefore, just altering the source of food (lab chow) can have marked effects on disease severity and outcome.


In the methods of a paper you write your methods such as "animals were fed on RM-1E diet ad libitum" etc. So animals were free access to given Rat Mouse One Expanded Diet. This study shows that diet can influence disease severity. I am sure many of you will say that diet can influence MS activity. Is it the content or is it that one batch  just tastes bad

A guy in the States once reported that if you feed pregant cats with irradiated diet you can get demyelination. Bizarre

9 comments:

  1. Excess of salt and/or sugar are inflammatory. Probably they have nothing to do as causation of the disease, but with the rapid progression of MS.

    I know some people here in Brazil and in the US that have adopted a food reeducation, rather decreasing the intake of salt, sugar and gluten, and are having good prognosis, and looks most like DMT uses the some CRABS. As I am curious I ask it, most who adopted a diet and the use of some DMT (have some that are only with the diet and the use of vitamin D3 daily) are between 03 - 06 years without outbreaks and disease progression. ..

    It reminded me of Diet Dr. Terry Wahls ...

    ReplyDelete
  2. What has happened to Prof G? Has he left the blog? Did someone insult him? We need him back. He needs to learn to ignore the trolls.

    ReplyDelete
    Replies
    1. I hope and pray that is not the case. Prof. G is such an inspiration to us.

      Delete
    2. Yep....is this the answer to Anon 9.45 or Ms Unites 6.23?

      Mojo problem?

      Delete
    3. Yep....is this the answer to Anon 9.45 or Ms Unites 6.23?

      Mojo problem?

      Delete
    4. His inspiration, humanitarianism and love for people is simply remarkable. I'd go as far to say in "modern times" from what I see he has done more for each and everyone of us with MS indirectly than any person on the planet. A very special person with a very special heart.

      Delete
  3. I found this on different numbered diets in my grad studies in one infection in particular. Chased a few leads but didn't find a mechanism before graduating so didn't publish it. Effect was pretty striking even though I had no proof what underpinned the difference.

    There was a strong facility effect too.


    I think things like this are why 'published science is not reproducible!' It probably is very reproducible, provided you replicate experimental conditions down to the right lab tech singing to the mice...

    ReplyDelete

Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.