Yesterday ,we described a model of MS presented to researchers, as a draining pond with lesions creating mini volcanoes.
This is based on recent article (click here)
To help us understand the pictures they gave us some videos too.
You may find them useful too.
RRMS vs SPMS.
In this video depiction of RRMS with early secondary progressive disease, relapsing disease transitions to SPMS with disability being driven in the early years by relapse (“base effects”) and in the later years primarily by the declining threshold (“surface effects”).
Highly active RRMS
In this video depiction of RRMS, highly active disease is characterized topographically by extensive clinical and sub-clinical inflammatory activity. Several lesions in the spinal cord and brainstem do not resolve below the clinical threshold, demonstrating lesions with high degree of severity and low capacity for recovery.
Mild RRMS with limited disability accumulation
In this video depiction of mild RRMS, no demonstrable disability is accumulated at 20 years of disease. All relapses resolve below the clinical threshold—demonstrating lesions with a high recovery capacity—and there is little depletion of functional reserve beyond that of normal aging.
In this video depiction of PPMS, several sub-threshold lesions, denoting underlying disease activity, do not cross the clinical threshold until functional reserve declines. Disability is driven over time by the dropping threshold.