What causes remyelination there is alot of interest in macrophages as they must clear up the debris of demyelination before remyelination can occur. In this study they find that a cytokine is more common in tissues about to repair than not repairing. However it does not make oligodendrocytes repair it simply blocks inflammation and if this is all it does then join the queue there are looks of things that block inflammation and many of them do it better. They find reduced clinical disease and surprise surprise then that they get less nerve damage and less inflammation allowing repair to progresses. So the message is stop damage and all repair mechanisms to work
If we look at the EAE data, it all sounds fanastic but look at the data and the figures don't add up. The effect of the treatment is marginal (Figure A), now look at figure D and the effect is enormous so abit of cherry picking of the figures and this is supported by figure E where the SMI-32 is reduced by about 60% but not out of existence as suggested by figure D. Now go to figure C and the gates (lines) go right through a population of cells.
Nice bit of reviewing:-(.