Ghasemi N, Razavi S, Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy. Cell J. 2017 Apr-Jun;19(1):1-10.
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction. Conventional therapies for MS are based on the use of anti-inflammatory and immunomodulatory drugs, but these treatments are not able to stop the destruction of nerve tissue. Thus, other strategies such as stem cell transplantation have been proposed for the treatment of MS. Overall, it is important that neurologists be aware of current information regarding the pathogenesis, etiology, diagnostic criteria, and treatment of MS. Thus, this issue has been discussed according to recent available information.
Cell is one of the most desirable journals in the world to publish in and there is a review of MS that starts "Overall, it is important that neurologists be aware of current information regarding the pathogenesis, aetiology, diagnostic criteria, and treatment of MS".
I thought it was funny a few scientists and a graduate study telling neurologists what to do,,it must be interesting, but then I noticed it was actually Cell Journal (one of those new internet journals) and my interest sank immediately
This is the pathogenis of EAE but says to me all researchers of MS should meet and see MS, before they attempt to study it. They may get a shock.