Friday, 12 May 2017

coffee what foodstuff next

Sharif K, Watad A, Bragazzi NL, Adawi M, Amital H, Shoenfeld Y. Coffee and autoimmunity: More than a mere hot beverage!
Autoimmun Rev. 2017 May 4. pii: S1568-9972(17)30127-1.

Coffee is one of the world's most consumed beverage. In the last decades, coffee consumption has attracted a huge body of research due to its impact on health. Recent scientific evidences showed that coffee intake could be associated with decreased mortality from cardiovascular and neurological diseases, diabetes type II, as well as from endometrial and liver cancer, among others. In this review, on the basis of available data in the literature, we aimed to investigate the association between coffee intake and its influence on the immune system and the insurgence of the most relevant autoimmune diseases. While some studies reported conflicting results, general trends have been identified. Coffee consumption seems to increase the risk of developing rheumatoid arthritis (RA) and type 1 diabetes mellitus (T1DM). By contrast, coffee consumption may exert a protective role against multiple sclerosis, primary sclerosing cholangitis, and ulcerative colitis. Concerning other autoimmune diseases such as systemic lupus erythematosus, psoriasis, primary biliary cholangitis and Crohn's disease, no significant association could be found. In other studies, coffee consumption was shown to influence disease course and management options. Coffee intake led to a decrease in insulin sensitivity in T1DM, in methotrexate efficacy in RA, and in levothyroxine absorption in Hashimoto's disease. Further, coffee consumption was associated with cross reactivity with gliadin antibodies in celiac patients. Data on certain autoimmune diseases like systemic sclerosis, Sjögren's syndrome, and Behçet's disease, among others, are lacking in the existent literature. As such, further research is warranted.

Only  20 million foodstuffs to go through, what next? Tonic water?, Cup cakes? This is the stuff that the media love. We could look at many things, but in isolation they provide small changes in risk. Is it the coffee? or are Coffee-drinkers are more social and pick up EBV differentially.


  1. They call MS an autoimmune disease in this. What would you personally put the likelihood of axon damage in MS being caused by the immune system as? Are we confident enough that we can finally rule out the theory that MS is solely is a neurodegenerative disease and that the immune system isn't the primary agent causing damage?

    I know it has been proposed that repeated attacks by the immune system trigger some sort of neurodegenerative process, but that still means that the immune system was the culprit in the first place.

    I guess my question is how out of the woods are we. What are the explanations for a lot of the early DMDs doing so little on disease progression despite doing fairly well on limiting relapses and lesions?

    1. Damage caused by the immune system...Likihood, I put it as high at the moment until someone proves this idea wrong.

      Protectiveimmunity to account why immune cells are in the brain, inflammation is may damage to get rid of problem then clear the MS up, but if immunity is the afterthought why do MS drugs work?

      In the animals we can have nerve damage without a T cell in sight yet we absolutely know that the problem was triggered by T cells in the first place.

      We have talked about immune failures in progression before, go into the education section to see how we explain it

  2. Replies
    1. Carrots grown in MD2's garden. Special nutrients yada yada ...

    2. If you click on the link to read it you'll only encourage them to write more ;-)

    3. "Yada Yada Yada"
      But we buy into it...I was shocked to come home to a tub of tumeric that MrsMouse had bought.

  3. MD: "but if immunity is the afterthought why do MS drugs work"

    Because the immune system reaction makes things much worse? But that doesn't preclude the possibility that the immune system reaction did not cause the initial damage/neurodegeneration?


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