Saturday, 14 October 2017

Depletion of neutrophils after alemtuzumab

Neutrophils are your first line of defence against infection, but they express CD52 and therefore they are depleted by alemtuzumab. This will contribute to infections post treatment, but, whilst common, the level of depletion is rarely severe and long-lasting.  We have commented on this in a previous postbut you can now get a free copy of the paper.






David Baker, Gavin Giovannoni, Klaus Schmierer 
Marked neutropenia: Significant but rare in people with multiple sclerosis after alemtuzumab treatment 
Multiple Sclerosis and Related Disorders 18 (2017) 181–183

https://authors.elsevier.com/a/1VtDp7skoetmzr

8 comments:

  1. 186 followers prove that you are not at all popular

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    1. ? Twitter I have 469 you have 1,034:-{, but I guess you are not popular with me:-(

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    2. Its hard being a scientist and being popular ....Often Times science is not a party
      Luis

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    3. Cd52 is present on the surface of mature sperm cells

      Another side efect of the drug reproductive male cells toxicity

      Obrigado

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  2. I so value your blog! Great timing for this linked paper as a starting point for me. 18 months post R2 lemtrada my neutrophils have tanked hard. Any others shares/experience appreciated!

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    1. Follow me on twitter as I will post the next install ment today

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    2. Hi MD, I followed to Twitter (my first time!), however still wondering your thoughts. Last 2 weeks neutrophils at/below 0.3, this being 18 months post R2 lemtrada. Company has referred to hematologist, still awaiting contact there. Is this consistent with published AI risk? Thanks fythoughts!

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    3. The AI (Autoimmunity) I suspect has little to do with a neutrophils, however they are important for infection control. It is good that you have been referred to a heamatologists and am happy that the company has taken an interest in your condition. Obviously there are ways to boost neutrophil numbers but your haematologist will know this.
      I hope their numbers increase.

      Best wishes

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