Will Biogen walk-the-talk and do another natalizumab SPMS trial?

At #MSParis207 I presented a new analysis of the data of the ASCEND trial (natalizumab in SPMS) that shows natalizumab is very effective in protecting upper limb function, and to a lesser extent lower limb function, in people with more advanced MS (majority needing walking aids). 

Will Biogen learn from this analysis and do an ASCEND-2 trial? If they cared about people with more advanced MS they would do this study. I also anticipate that in the future PML will not be a problem; we will have antivirals that will clear the body of JCV and the risk of PML as a complication of natalizumab treatment will become very, very, low. The latter is another reason for doing this study.

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